Kristev A, Mitkov D, Lukanov Y
Department of Pathophysiology, I. P. Pavlov Medical Institute, Plovdiv, Bulgaria.
Cor Vasa. 1987;29(4):313-8.
The influence of sodium salt of butyric acid (C4H7NaO2) on the functional state of the cardiovascular system was studied on 12 guinea-pigs and 15 rabbits by the thermodilution method. The following parameters were determined: cardiac output (CO), arterial blood pressure (AP), total peripheral vascular resistance (TPVR), and in rabbits the heart rate (HR). It was found that butyric acid induces significant changes in TPVR, which correlate with changes in CO and AP. These changes could to a considerable extent be prevented by the administration of indomethacin. Haemodynamic changes induced by butyric acid are primarily connected with changes in vascular tonus, induced by the action of F2 alpha prostaglandins whose synthesis is intensified by the influence of butyric acid.
通过热稀释法，在12只豚鼠和15只兔子身上研究了丁酸钠（C4H7NaO2）对心血管系统功能状态的影响。测定了以下参数：心输出量（CO）、动脉血压（AP）、总外周血管阻力（TPVR），在兔子身上还测定了心率（HR）。发现丁酸可引起TPVR的显著变化，这与CO和AP的变化相关。吲哚美辛的给药在很大程度上可以预防这些变化。丁酸引起的血流动力学变化主要与血管张力的变化有关，血管张力的变化是由F2α前列腺素的作用引起的，丁酸的影响会增强F2α前列腺素的合成。
