Supra Rajiv, Agrawal Devendra K
College of Osteopathic Medicine, Touro University, Henderson, Nevada.
Department of Translational Research, Western University of Health Sciences, 309 E. Second Street, Pomona, California 91766-1854, USA.
J Orthop Sports Med. 2023;5(1):9-19. doi: 10.26502/josm.511500073. Epub 2022 Dec 5.
The total joint replacement is recognized as one of the most effective medical arbitrations leading to increased mobility, pain relief, and an overall restored function of the joint. Unfortunately, prosthetic debris accumulates after long-term wear of the implant leading to activation of the innate immune response and periprosthetic osteolysis. Understanding the intricate biological mechanisms underlying the innate immune response to implant debris would support the development of novel pharmacological treatments to prolong the life span of the implant. This article provides a detailed description on the role of the innate immune system in response to implant debris, emphasizing the most recent research and outstanding questions. Furthermore, a critical discussion is presented on the novel pharmacological treatments currently under investigation to prevent implant failure.
全关节置换被认为是最有效的医学干预措施之一，可提高关节活动度、缓解疼痛并全面恢复关节功能。不幸的是，植入物长期磨损后会积累假体碎片，导致先天性免疫反应激活和假体周围骨溶解。了解对植入物碎片的先天性免疫反应背后复杂的生物学机制，将有助于开发新的药物治疗方法，以延长植入物的使用寿命。本文详细描述了先天性免疫系统在应对植入物碎片中的作用，强调了最新研究和突出问题。此外，还对目前正在研究的预防植入物失败的新型药物治疗进行了批判性讨论。
