Gilbard J P, Hanninen L A, Rothman R C, Kenyon K R
Eye Research Institute, Boston, MA 02114.
Curr Eye Res. 1987 Oct;6(10):1237-48. doi: 10.3109/02713688709025234.
The NZB/NZW F1 hybrid mouse has been reported to contract a disease similar to Sjögren's syndrome in man. We studied lacrimal gland morphology, corneal morphology, and tear osmolarity in this mouse as a function of age. Lacrimal glands of hybrid mice contained abnormal periductal infiltrates of lymphocytes and plasma cells. Maximum infiltration of the lacrimal gland occurred in the 29-week-old female hybrid mouse and was estimated to involve 12% of the gland, but was insufficient to alter tear osmolarity relative to DBA and Balb/c control mice. Nevertheless, both NZB/NZW F1 hybrid mice and DBA and Balb/c control mice had tear osmolarity and corneal surface morphology similar to that reported for keratoconjunctivitis sicca in man. Although the NZB/NZW F1 hybrid mouse may provide a valuable model for the study of lacrimal gland infiltration, since its tear osmolarity and ocular surface remain normal for a mouse, its usefulness as a model for ocular surface disease in human keratoconjunctivitis sicca may be more limited than previously thought.
据报道，NZB/NZW F1杂交小鼠会患上一种与人类干燥综合征相似的疾病。我们研究了这种小鼠的泪腺形态、角膜形态以及泪液渗透压随年龄的变化情况。杂交小鼠的泪腺含有异常的导管周围淋巴细胞和浆细胞浸润。泪腺的最大浸润发生在29周龄的雌性杂交小鼠中，估计累及腺体的12%，但相对于DBA和Balb/c对照小鼠而言，这不足以改变泪液渗透压。尽管如此，NZB/NZW F1杂交小鼠以及DBA和Balb/c对照小鼠的泪液渗透压和角膜表面形态与人类干燥性角结膜炎的报道相似。虽然NZB/NZW F1杂交小鼠可能为泪腺浸润研究提供有价值的模型，但由于其泪液渗透压和眼表对于小鼠来说仍属正常，它作为人类干燥性角结膜炎眼表疾病模型的实用性可能比之前认为的更有限。
