Wang Yun, Li Xiaoling, Yan Haohao, Zhang Qinqin, Ou Yangpan, Wu Weibin, Shangguan Webo, Chen Wensheng, Yu Yang, Liang Jiaquan, Wu Wanting, Liao Hairong, Liu Zishan, Mai Xiancong, Xie Guojun, Guo Wenbin
Department of Psychiatry, The Third People's Hospital of Foshan, Foshan, Guangdong, China.
Department of Psychiatry, National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Front Psychol. 2023 Jan 26;13:1090181. doi: 10.3389/fpsyg.2022.1090181. eCollection 2022.
This study aimed to investigate the relationships between regional neural activity and multiple related indicators in patients with major depressive disorder (MDD).
Forty-two patients and 42 healthy controls (HCs) were enrolled. Pearson/Spearman correlation analyses were applied to examine the associations between abnormal regional homogeneity (ReHo) and different indicators in the patients.
Compared with HCs, patients with MDD had increased ReHo in the left inferior temporal gyrus (ITG) and decreased ReHo values in the left putamen, anterior cingulate cortex (ACC), and precentral gyrus. The ReHo of the left putamen was positively correlated with the PR interval, Repeatable Battery for the Assessment of Neuropsychological Status 4A, and Discriminant analysis (D), and negatively correlated with Ae (block) and Ae (total) in the patients. The ReHo value of the left ACC was positively correlated with the severity of depression, Stroop Color Word Test of C - 2B + 100 in reaction time, and negatively correlated with Ce (Missay) and Perseverative Responses in the patients. The ReHo of the left ITG was positively correlated with the Neuroticism scores and negatively correlated with the Lie scores in the patients.
These results suggested that the decreased ReHo of the salience network might be the underpinning of cognitive impairments in patients with MDD.
本研究旨在探讨重度抑郁症（MDD）患者区域神经活动与多个相关指标之间的关系。
招募了42例患者和42名健康对照者（HCs）。应用Pearson/Spearman相关性分析来检验患者异常局部一致性（ReHo）与不同指标之间的关联。
与HCs相比，MDD患者左侧颞下回（ITG）的ReHo增加，而左侧壳核、前扣带回皮质（ACC）和中央前回的ReHo值降低。患者左侧壳核的ReHo与PR间期、可重复神经心理状态评估量表4A及判别分析（D）呈正相关，与Ae（阻滞）和Ae（总计）呈负相关。患者左侧ACC的ReHo值与抑郁严重程度、C-2B+100的Stroop色词测验反应时间呈正相关，与Ce（说错）和持续性反应呈负相关。患者左侧ITG的ReHo与神经质得分呈正相关，与说谎得分呈负相关。
这些结果表明，突显网络的ReHo降低可能是MDD患者认知障碍的基础。
