成人早发性与晚发性复发性抑郁症静息态功能磁共振成像局部一致性的比较研究
A Comparative Study of Regional Homogeneity of Resting-State fMRI Between the Early-Onset and Late-Onset Recurrent Depression in Adults.
作者信息
Sun Ji-Fei, Chen Li-Mei, He Jia-Kai, Wang Zhi, Guo Chun-Lei, Ma Yue, Luo Yi, Gao De-Qiang, Hong Yang, Fang Ji-Liang, Xu Feng-Quan
机构信息
Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Graduate School of China Academy of Chinese Medical Sciences, Beijing, China.
出版信息
Front Psychol. 2022 Apr 7;13:849847. doi: 10.3389/fpsyg.2022.849847. eCollection 2022.
BACKGROUND
Neurobiological mechanisms underlying the recurrence of major depressive disorder (MDD) at different ages are unclear, and this study used the regional homogeneity (ReHo) index to compare whether there are differences between early onset recurrent depression (EORD) and late onset recurrent depression (LORD).
METHODS
Eighteen EORD patients, 18 LORD patients, 18 young healthy controls (HCs), and 18 older HCs were included in the rs-fMRI scans. ReHo observational metrics were used for image analysis and further correlation of differential brain regions with clinical symptoms was analyzed.
RESULTS
ANOVA analysis revealed significant differences between the four groups in ReHo values in the prefrontal, parietal, temporal lobes, and insula. Compared with EORD, the LORD had higher ReHo in the right fusiform gyrus/right middle temporal gyrus, left middle temporal gyrus/left angular gyrus, and right middle temporal gyrus/right angular gyrus, and lower ReHo in the right inferior frontal gyrus/right insula and left superior temporal gyrus/left insula. Compared with young HCs, the EORD had higher ReHo in the right inferior frontal gyrus/right insula, left superior temporal gyrus/left insula, and left rolandic operculum gyrus/left superior temporal gyrus, and lower ReHo in the left inferior parietal lobule, right inferior parietal lobule, and left middle temporal gyrus/left angular gyrus. Compared with old HCs, the LORD had higher ReHo in the right fusiform gyrus/right middle temporal gyrus, right middle temporal gyrus/right angular gyrus, and left rolandic operculum gyrus/left superior temporal gyrus, and lower ReHo in the right inferior frontal gyrus/right insula. ReHo in the right inferior frontal gyrus/right insula of patients with LORD was negatively correlated with the severity of 17-item Hamilton Rating Scale for Depression (HAMD-17) scores ( = -0.5778, = 0.0120).
CONCLUSION
Adult EORD and LORD patients of different ages have abnormal neuronal functional activity in some brain regions, with differences closely related to the default mode network (DMN) and the salience network (SN), and patients of each age group exhibit ReHo abnormalities relative to matched HCs.
CLINICAL TRIAL REGISTRATION
[http://www.chictr.org.cn/], [ChiCTR1800014277].
背景
不同年龄重度抑郁症（MDD）复发的神经生物学机制尚不清楚，本研究使用局部一致性（ReHo）指数比较早发性复发性抑郁症（EORD）和晚发性复发性抑郁症（LORD）之间是否存在差异。
方法
18例EORD患者、18例LORD患者、18例年轻健康对照者（HCs）和18例老年HCs纳入静息态功能磁共振成像（rs-fMRI）扫描。采用ReHo观测指标进行图像分析，并进一步分析差异脑区与临床症状的相关性。
结果
方差分析显示，四组在前额叶、顶叶、颞叶和脑岛的ReHo值存在显著差异。与EORD相比，LORD在右侧梭状回/右侧颞中回、左侧颞中回/左侧角回以及右侧颞中回/右侧角回的ReHo较高，而在右侧额下回/右侧脑岛和左侧颞上回/左侧脑岛的ReHo较低。与年轻HCs相比，EORD在右侧额下回/右侧脑岛、左侧颞上回/左侧脑岛以及左侧中央前回盖/左侧颞上回的ReHo较高，而在左侧顶下小叶、右侧顶下小叶以及左侧颞中回/左侧角回的ReHo较低。与老年HCs相比，LORD在右侧梭状回/右侧颞中回、右侧颞中回/右侧角回以及左侧中央前回盖/左侧颞上回的ReHo较高，而在右侧额下回/右侧脑岛的ReHo较低。LORD患者右侧额下回/右侧脑岛的ReHo与17项汉密尔顿抑郁量表（HAMD-17）评分的严重程度呈负相关（r = -0.5778，P = 0.0120）。
结论
不同年龄的成年EORD和LORD患者在某些脑区存在神经元功能活动异常，这些差异与默认模式网络（DMN）和突显网络（SN）密切相关，且各年龄组患者相对于匹配的HCs均表现出ReHo异常。
临床试验注册
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