Rozga J, Jeppsson B, Bengmark S
Br J Exp Pathol. 1985 Dec;66(6):669-78.
The hepatotrophic effect of portal blood was studied in rats with portal branch ligation (PBL) simultaneously subjected to mesocaval shunt or total hepatic arterialization. A direct supply of the nonligated liver lobes with pancreatic effluent did not improve DNA synthesis or mitotic response compared to arterialized rats, in which the portal-borne hepatotrophic factors reached the same lobes after systemic recirculation. A comparison with shunted but Sham-PBL rats showed that restorative capacity of the liver was not seriously impaired. In rats with PBL alone the lobes with portal occlusion showed extensive necrosis. In contrast, in PBL + shunt rats necrosis was significantly inhibited, indicating a hepatoprotective role of portal blood during hepatic arterial recirculation. Thus, the study suggests that quality of hepatic blood supply is of vital importance in maintenance of hepatocellular integrity. Hemodynamical factors seem to be of importance, but more in a sense of increased or decreased accessibility of humoral hepatotrophic factors in the blood.
在同时进行门腔分流或全肝动脉化的门静脉分支结扎（PBL）大鼠中，研究了门静脉血的肝营养作用。与动脉化大鼠相比，直接将胰腺流出液供应给未结扎的肝叶并不能改善DNA合成或有丝分裂反应，在动脉化大鼠中，门静脉携带的肝营养因子在全身再循环后到达相同的肝叶。与分流但假手术PBL大鼠的比较表明，肝脏的恢复能力没有受到严重损害。在仅进行PBL的大鼠中，门静脉闭塞的肝叶出现广泛坏死。相比之下，在PBL+分流大鼠中，坏死明显受到抑制，表明门静脉血在肝动脉再循环期间具有肝保护作用。因此，该研究表明肝血供质量对维持肝细胞完整性至关重要。血流动力学因素似乎很重要，但更多的是从血液中体液性肝营养因子可及性增加或减少的意义上来说。
