Department of Materials Science and Engineering, Southern University of Science and Technology, Shenzhen, Guangdong 518055, China.
Department of Mechanical and Aerospace Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong 999077, China.
ACS Biomater Sci Eng. 2023 Mar 13;9(3):1720-1728. doi: 10.1021/acsbiomaterials.2c01239. Epub 2023 Feb 13.
Porous tantalum (Ta) is a potential bone substitute due to its excellent biocompatibility and desirable mechanical properties. In this work, a series of porous Ta materials with interconnected micropores and varying pore sizes from 23 to 210 μm were fabricated using spark plasma sintering. The porous structure was formed by thermal decomposition of ammonium bicarbonate powder premixed in the Ta powder. The pore size and porosity were controlled by the categorized particle size of ammonium bicarbonate. The porous Ta has elastic moduli in the range of 2.1-3.2 GPa and compressive yield strength in the range of 23-34 MPa, which are close to those of human bone. , as-fabricated porous Ta demonstrates excellent biocompatibility by supporting adhesion and proliferation of preosteoblasts. studies also validate its bone repair capability after implantation in a rat femur defect model. The study demonstrates a facile strategy to fabricate porous Ta with controllable pore size for bone repair.
多孔钽（Ta）因其优异的生物相容性和理想的机械性能，是一种有潜力的骨替代材料。在这项工作中，采用火花等离子烧结技术制备了一系列具有相互连通的微孔和不同孔径（23-210μm）的多孔 Ta 材料。多孔结构是由预先混入 Ta 粉末中的碳酸氢铵粉末热分解形成的。孔径和孔隙率通过碳酸氢铵的分类粒径来控制。多孔 Ta 的弹性模量在 2.1-3.2GPa 范围内，压缩屈服强度在 23-34MPa 范围内，接近人体骨骼。此外，所制备的多孔 Ta 支持成骨前体细胞的黏附和增殖，表现出优异的生物相容性。体内研究还验证了其在大鼠股骨缺损模型中的骨修复能力。该研究为制备用于骨修复的具有可控孔径的多孔 Ta 提供了一种简便的策略。
