School of Speech, Language, and Hearing Sciences, San Diego State University, CA.
School of Communication Science and Disorders, Florida State University, Tallahassee.
J Speech Lang Hear Res. 2023 Mar 7;66(3):804-819. doi: 10.1044/2022_JSLHR-22-00443. Epub 2023 Feb 13.
Despite the overall benefits of deep brain stimulation (DBS) in Parkinson's disease (PD), its effects on speech production have been mixed when examined using auditory-perceptual and acoustic measures. This study investigated the effects of DBS on the lip and jaw kinematics during sentence production in individuals with dysarthria secondary to PD.
Twenty-seven participants from three groups were included in the study: (a) individuals with PD and without DBS (PD group), (b) individuals with PD and with DBS (PD-DBS group), and (c) neurologically healthy control speakers (HC group). Lip and jaw movements during speech were recorded using optical motion capture and analyzed for path distance, speed, duration, articulatory stability, and interarticulator coordination.
The PD-DBS group showed (a) increased path distance compared with the PD and HC groups and (b) increased speed compared with the PD group but not the HC group. Both PD and PD-DBS groups exhibited lengthened sentence duration compared with the HC group. Articulatory stability was greater for the two PD groups, PD and PD-DBS, compared with the HC group. Spatial, but not temporal, coordination was lower for the PD group than for the other two groups. The only kinematic changes between the DBS on and off conditions within the PD-DBS group were increases in spatial coordination.
These data suggest that DBS primarily affects the amplitude scaling of articulatory movements, but not the temporal scaling, in individuals with PD. The findings are discussed with respect to the DBS-induced neural changes and their effects on speech motor control in PD.
尽管深部脑刺激（DBS）对帕金森病（PD）整体有益，但使用听觉感知和声学测量方法检查时，其对言语产生的影响却不一致。本研究调查了 DBS 对 PD 继发构音障碍个体在句子产生过程中唇和颌运动的影响。
本研究纳入了三个组别的 27 名参与者：（a）无 DBS 的 PD 患者（PD 组），（b）有 DBS 的 PD 患者（PD-DBS 组）和（c）神经健康的对照组说话者（HC 组）。使用光学运动捕捉记录说话时的唇和颌运动，并对路径距离、速度、时长、发音稳定性和发音器官协调性进行分析。
PD-DBS 组与 PD 组和 HC 组相比，（a）路径距离增加，（b）速度增加，而与 HC 组相比，速度增加。PD 组和 PD-DBS 组的句子时长均比 HC 组长。与 HC 组相比，PD 和 PD-DBS 两个 PD 组的发音稳定性更高。PD 组的空间协调性低于其他两组，而时间协调性无差异。PD-DBS 组中 DBS 开和关状态之间的唯一运动学变化是空间协调性增加。
这些数据表明，DBS 主要影响 PD 个体发音运动的幅度缩放，而不是时间缩放。研究结果与 DBS 诱导的神经变化及其对 PD 言语运动控制的影响进行了讨论。
