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腹足纲软体动物罗马蜗牛神经系统和心脏对章鱼胺的体外生物合成（作者译）

[In vitro biosynthesis of octopamine by the nervous system and the heart of the mollusc gastropode Helix pomatia (author's transl)].

作者信息

Cardot J

出版信息

Experientia. 1978 Oct 15;34(10):1261-3. doi: 10.1007/BF01981405.

DOI:10.1007/BF01981405
PMID:367806
Abstract

The tyrosine is decarboxylated in vitro by the central nervous tissue and by the intracardiac nervous tissue of Helix pomatia by aromatic amino-acid decarboxylase. The tyramine obtained is then partially transformed into octopamine by tyramine-beta-hydroxylase. The inhibition of monoamine oxidase favours apparition of the 2 amines. The monoamine oxidase seems able to regulate their synthese and to assure their inactivation.

摘要

酪氨酸在体外可被芳香族氨基酸脱羧酶作用，由波氏圆田螺的中枢神经组织和心脏内神经组织进行脱羧反应。生成的酪胺随后部分被酪胺-β-羟化酶转化为章鱼胺。单胺氧化酶的抑制有利于这两种胺的出现。单胺氧化酶似乎能够调节它们的合成并确保其失活。

相似文献

1
[In vitro biosynthesis of octopamine by the nervous system and the heart of the mollusc gastropode Helix pomatia (author's transl)].腹足纲软体动物罗马蜗牛神经系统和心脏对章鱼胺的体外生物合成（作者译）
Experientia. 1978 Oct 15;34(10):1261-3. doi: 10.1007/BF01981405.
2
[The monoamines in molluscs. I. Catecholamines: biosynthesis, disposition and inactivation (author's transl)].[软体动物中的单胺。I. 儿茶酚胺：生物合成、分布与失活（作者译）]
J Physiol (Paris). 1979;75(7):689-713.
3
The biosynthesis of octopamine.章鱼胺的生物合成。
Naunyn Schmiedebergs Arch Pharmacol. 1972;273(1):123-33. doi: 10.1007/BF00508085.
4
Trace amines differentially regulate adult locomotor activity, cocaine sensitivity, and female fertility in Drosophila melanogaster.痕量胺对黑腹果蝇的成年运动活动、可卡因敏感性和雌性生育能力有不同的调节作用。
Dev Neurobiol. 2007 Sep 1;67(10):1396-405. doi: 10.1002/dneu.20459.
5
[Studies on catecholamine biosynthesis. IV. Inhibition of dopamine beta-hydroxylase by thiourea derivatives (author's transl)].[儿茶酚胺生物合成的研究。IV. 硫脲衍生物对多巴胺β-羟化酶的抑制作用（作者译）]
Yakugaku Zasshi. 1975 Apr;95(4):373-7. doi: 10.1248/yakushi1947.95.4_373.
6
[Dopamine and monoamine oxidase in the mollusc Helix pomatia. In vitro production of 3, 4-dihydroxyphenylacetic acid].[软体动物皱疤坚螺中的多巴胺和单胺氧化酶。3,4-二羟基苯乙酸的体外产生]
C R Seances Soc Biol Fil. 1972 Nov 9;166(2):336-9.
7
Prenatal ontogenesis of p-, m-octopamine and phenylethanolamine in relation to catecholamines and their metabolizing enzymes in the developing rat brain and heart.
Neuroscience. 1984 Aug;12(4):1271-6. doi: 10.1016/0306-4522(84)90020-4.
8
Formation of 14 C-octopamine from 14 C-tyramine in the mouse: a dose dependent relationship.小鼠体内14C-酪胺生成14C-章鱼胺：剂量依赖关系。
Acta Physiol Scand. 1971 Aug;82(4):571-3. doi: 10.1111/j.1748-1716.1971.tb05004.x.
9
Biosynthesis of cerebral phenolic amines. II. In vivo regional formation of p-tyramine and octopamine from tyrosine and dopamine.脑酚胺的生物合成。II. 体内由酪氨酸和多巴胺区域形成对酪胺和章鱼胺。
Can J Biochem. 1973 Apr;51(4):428-35. doi: 10.1139/o73-050.
10
Restoration of the chronotropic effect of tyramine on rat atria after reserpine.利血平处理后酪氨酸对大鼠心房变时作用的恢复。
Br J Pharmacol. 1968 Sep;34(1):88-98. doi: 10.1111/j.1476-5381.1968.tb07953.x.

本文引用的文献

1
Identification of octopamine as l-p-hydroxyphenylethanolamine.将章鱼胺鉴定为1-对羟基苯乙醇胺。
Nature. 1952 Mar 1;169(4296):375-6. doi: 10.1038/169375b0.
2
[The free amino acid constituent of the heart of Helix pomatia].[苹果螺心脏中的游离氨基酸成分]
C R Seances Soc Biol Fil. 1961;155:819-20.
3
[5-HYDROXYTRYPTOPHAN DOPA DECARBOXYLASE IN NERVOUS AND CARDIAC TISSUES IN THE MOLLUSC HELIX POMATIA. INTERACTION OF SUBSTRATES IN VITRO].
C R Hebd Seances Acad Sci. 1964 Jul 27;259:902-4.
4
[Research on the free amino acid composition of the nervous system of Helix pomatia].[关于苹果螺神经系统游离氨基酸组成的研究]
C R Seances Soc Biol Fil. 1961;155:1961-3.
5
Serotonin, free amino-acids, and related substances occurring in the blood and nervous tissue of Helix aspersa (gastropoda mollusca).在庭院蜗牛（腹足纲软体动物）的血液和神经组织中发现的血清素、游离氨基酸及相关物质。
Comp Gen Pharmacol. 1972 Jun;3(10):171-7. doi: 10.1016/0010-4035(72)90023-7.
6
The presence of octopamine in the brain of Helix aspersa and its action on specific snail neurones.
Experientia. 1972 Oct 15;28(10):1173-4. doi: 10.1007/BF01946151.
7
Biosynthesis of cerebral phenolic amines. I. In vivo formation of p-tyramine, octopamine, and synephrine.脑酚胺的生物合成。I. 对酪胺、章鱼胺和辛弗林的体内形成。
Can J Biochem. 1972 Mar;50(3):261-7. doi: 10.1139/o72-037.
8
Choline acetyltransferase, acetylcholinesterase and aromatic L-amino acid decarboxylase in single identified nerve cell bodies from snail Helix aspersa.来自蜗牛（Helix aspersa）单个已鉴定神经细胞体中的胆碱乙酰转移酶、乙酰胆碱酯酶和芳香族L-氨基酸脱羧酶。
J Neurochem. 1974 Jun;22(6):1079-88. doi: 10.1111/j.1471-4159.1974.tb04340.x.
9
Intrasomatic injection of radioactive precursors for studying transmitter synthesis in identified neurons of Aplysia californica.体内注射放射性前体以研究加州海兔特定神经元中的递质合成。
Proc Natl Acad Sci U S A. 1973 Dec;70(12):3371-5. doi: 10.1073/pnas.70.12.3371.
10
Metabolism of putative transmitters in individual neurons of Aplysia californica: aromatic amino acid decarboxylase.加州海兔单个神经元中假定递质的代谢：芳香族氨基酸脱羧酶
J Neurochem. 1972 Apr;19(4):1125-30. doi: 10.1111/j.1471-4159.1972.tb01432.x.