Ophthalmic Surg Lasers Imaging Retina. 2023 Feb;54(2):78-83. doi: 10.3928/23258160-20230117-01. Epub 2023 Feb 1.
To evaluate the impact on trends in clinical presentation of acute, primary rhegmatogenous retinal detachments (RRD) from early to late phases of the COVID-19 pandemic.
This study was a single-center, consecutive case series of 1,727 patients treated after vaccine availability ("late"; 3/29/21 to 9/26/21), corresponding time frame in previous year of pandemic ("early"; 3/30/20 to 9/27/20), and prior to pandemic ("pre"; 4/1/19 to 9/29/19). Primary outcome was proportion of patients presenting with macula-off RRD. Secondary outcomes included best-corrected visual acuity (BCVA) and primary proliferative vitreoretinopathy (PVR).
While macula-off RRD rates were significantly ( < 0.0001) elevated in early and late cohorts compared to the pre cohort, only the early cohort showed a significant ( < 0.0001) increase in both primary PVR presentation and complex RRD repair. Patients lost to follow-up in early cohort were significantly ( < 0.0001) higher than others. Early cohort showed significantly ( < 0.0001) worse final BCVA compared to others.
Patients in late pandemic were less likely to exhibit clinical features of worse RRD disease and have improved visual outcomes compared to those in early pandemic. .
评估 COVID-19 大流行早、晚期急性原发性孔源性视网膜脱离（RRD）临床发病趋势的影响。
这是一项单中心、连续病例系列研究，共纳入 1727 例患者，均在疫苗可及后（“晚期”：2021 年 3 月 29 日至 9 月 26 日）、大流行前一年同期（“早期”：2020 年 3 月 30 日至 9 月 27 日）和大流行前（“前期”：2019 年 4 月 1 日至 9 月 29 日）接受治疗。主要结局为表现为黄斑脱离性 RRD 的患者比例。次要结局包括最佳矫正视力（BCVA）和原发性增生性玻璃体视网膜病变（PVR）。
虽然早期和晚期队列的黄斑脱离性 RRD 发生率明显（<0.0001）高于前期队列，但只有早期队列表现出原发性 PVR 发生率和复杂 RRD 修复率均显著（<0.0001）增加。早期队列中失访患者明显（<0.0001）高于其他队列。早期队列的最终 BCVA明显（<0.0001）差于其他队列。
与早期大流行相比，晚期大流行的患者表现出更严重 RRD 疾病的临床特征的可能性较低，且视觉结局得到改善。
