Division of Development and Growth, Department of Paediatrics, Gynaecology and Obstetrics, Geneva University Hospitals, Geneva, Switzerland; Neuro-X Institute, École Polytechnique Fédérale de Lausanne, Geneva, Switzerland; Department of Radiology and Medical Informatics, Faculty of Medicine, University of Geneva, Switzerland.
Division of Development and Growth, Department of Paediatrics, Gynaecology and Obstetrics, Geneva University Hospitals, Geneva, Switzerland; SensoriMotor, Affective and Social Development Laboratory, Faculty of Psychology and Educational Sciences, University of Geneva, Geneva, Switzerland.
Dev Cogn Neurosci. 2023 Apr;60:101211. doi: 10.1016/j.dcn.2023.101211. Epub 2023 Feb 6.
Previous studies suggest that structural alteration of the corpus callosum, i.e., the largest white matter commissural pathway, occurs after a preterm birth in the neonatal period and lasts across development. The present study aims to unravel corpus callosum structural characteristics across childhood and adolescence in very preterm (VPT) individuals, and their associations with general intellectual, executive and socio-emotional functioning. Neuropsychological assessments, T1-weighted and multi-shell diffusion MRI were collected in 79 VPT and 46 full term controls aged 6-14 years. Volumetric, diffusion tensor and neurite orientation dispersion and density imaging (NODDI) measures were extracted on 7 callosal portions using TractSeg. A multivariate data-driven approach (partial least squares correlation) and a cohort-based age normative modelling approach were used to explore associations between callosal characteristics and neuropsychological outcomes. The VPT and a full-term control groups showed similar trends of white-matter maturation over time, i.e., increase FA and reduced ODI, in all callosal segments, that was associated with increase in general intellectual functioning. However, using a cohort-based age-related normative modelling, findings show atypical pattern of callosal development in the VPT group, with reduced callosal maturation over time that was associated with poorer general intellectual and working memory functioning, as well as with lower gestational age.
先前的研究表明，在新生儿期经历早产儿出生后，胼胝体（即最大的白质联合通路）的结构会发生改变，并持续到发育过程中。本研究旨在揭示早产儿个体在儿童期和青春期胼胝体的结构特征，以及它们与一般智力、执行功能和社会情感功能的关系。在 6-14 岁的 79 名极早产儿（VPT）和 46 名足月对照组中，收集了神经心理学评估、T1 加权和多壳扩散 MRI。使用 TractSeg 在 7 个胼胝体部位提取体积、扩散张量和神经丝取向分散和密度成像（NODDI）测量值。使用多元数据驱动方法（偏最小二乘相关）和基于队列的年龄规范建模方法，探索了胼胝体特征与神经心理学结果之间的关系。VPT 和足月对照组在所有胼胝体区域均显示出相似的白质成熟时间趋势，即 FA 增加和 ODI 降低，这与一般智力的提高有关。然而，使用基于队列的年龄相关规范建模，研究结果表明 VPT 组的胼胝体发育存在异常模式，随着时间的推移，胼胝体的成熟度降低，与一般智力和工作记忆功能下降以及较低的胎龄有关。
