Chen Jing, Li Meihui, Lu Hongyang
Zhejiang Key Laboratory of Diagnosis & Treatment Technology on Thoracic Oncology (lung and esophagus), Zhejiang Cancer Hospital, Institute of Basic and Cancer Medicine (IBCM), 310022, P.R. China; Department of Thoracic Medical Oncology, Zhejiang Cancer Hospital, Institute of Basic and Cancer Medicine (IBCM), 310022, P.R. China; Wenzhou Medical University, Wenzhou, 325035, P.R. China.
Zhejiang Key Laboratory of Diagnosis & Treatment Technology on Thoracic Oncology (lung and esophagus), Zhejiang Cancer Hospital, Institute of Basic and Cancer Medicine (IBCM), 310022, P.R. China; Department of Thoracic Medical Oncology, Zhejiang Cancer Hospital, Institute of Basic and Cancer Medicine (IBCM), 310022, P.R. China; The First Clinical Medical College, Wenzhou Medical University, Wenzhou, 325035, P.R. China.
Transl Oncol. 2023 Apr;30:101640. doi: 10.1016/j.tranon.2023.101640. Epub 2023 Feb 11.
Nuclear protein in testis (NUT) carcinoma is a kind of highly aggressive and fatal solid tumor characterized by a rearrangement of the NUT carcinoma family member 1 (NUTM1) gene located on chromosome 15 q l4, where the most common form of fusion is BRD4-NUT. NUT carcinoma occurred in different organs and was most commonly found in the midline organs and the lungs. NUT carcinoma can occur in patients of almost all ages, having a roughly consistent incidence in both sexes. Most of the patients were diagnosed in advanced stages with an extremely poor prognosis due to the lack of effective treatment. After years of research, the mechanism of NUT carcinoma is still not fully clear, and its therapeutic approaches need to be further studied and explored. In order to gain a more comprehensive understanding of NUT carcinoma and explore the effective treatments, this review aimed to summarize the clinical features, pathological characteristics, differential diagnosis, and treatment strategies for this disease.
睾丸核蛋白（NUT）癌是一种高度侵袭性和致命性的实体瘤，其特征是位于15号染色体q14上的NUT癌家族成员1（NUTM1）基因发生重排，最常见的融合形式是BRD4-NUT。NUT癌发生于不同器官，最常见于中线器官和肺部。NUT癌几乎可发生于所有年龄段的患者，男女发病率大致相当。由于缺乏有效治疗，大多数患者在晚期被诊断出来，预后极差。经过多年研究，NUT癌的发病机制仍不完全清楚，其治疗方法有待进一步研究和探索。为了更全面地了解NUT癌并探索有效的治疗方法，本综述旨在总结该疾病的临床特征、病理特征、鉴别诊断和治疗策略。
