Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland.
Service of Nephrology and Hypertension, Lausanne University Hospital, Lausanne, Switzerland.
Kidney Blood Press Res. 2023;48(1):194-201. doi: 10.1159/000529094. Epub 2023 Feb 13.
Kidney stone disease has a high prevalence worldwide of approximately 10% of the population and is characterized by a high recurrence rate. Kidney stone disease results from a combination of genetic, environmental, and lifestyle risk factors, and the dissection of these factors is complex.
The Swiss Kidney Stone Cohort (SKSC) is an investigator-initiated prospective, multicentric longitudinal, observational study in patients with kidney stones followed with regular visits over a period of 3 years after inclusion. Ongoing follow-ups by biannual telephone interviews will provide long-term outcome data. SKSC comprises 782 adult patients (age >18 years) with either recurrent stones or a single stone event with at least one risk factor for recurrence. In addition, a control cohort of 207 individuals without kidney stone history and absence of kidney stones on a low-dose CT scan at enrolment has also been recruited. SKSC includes extensive collections of clinical data, biochemical data in blood and 24-h urine samples, and genetic data. Biosamples are stored at a dedicated biobank. Information on diet and dietary habits was collected through food frequency questionnaires and standardized recall interviews by trained dieticians with the Globodiet software.
SKSC provides a unique opportunity and resource to further study cause and course of kidney disease in a large population with data and samples collected of a homogeneous collective of patients throughout the whole Swiss population.
肾结石疾病在全球的患病率约为 10%，具有很高的复发率。肾结石疾病是由遗传、环境和生活方式等多种因素共同作用的结果，这些因素的剖析非常复杂。
瑞士肾结石队列研究（SKSC）是一项由研究者发起的前瞻性、多中心、纵向、观察性研究，纳入了肾结石患者，并在纳入后 3 年内定期随访。通过每两年一次的电话访谈进行的持续随访将提供长期的预后数据。SKSC 包括 782 名成年患者（年龄＞18 岁），这些患者要么有复发性结石，要么有单发结石且至少有一个复发的危险因素。此外，还招募了 207 名无肾结石病史且在入组时低剂量 CT 扫描无肾结石的对照组个体。SKSC 包括广泛的临床数据、血液和 24 小时尿液样本的生化数据以及遗传数据。生物样本存储在专门的生物库中。通过Globodiet 软件，由经过培训的营养师进行食物频率问卷调查和标准化回忆访谈，收集饮食和饮食习惯信息。
SKSC 为在整个瑞士人群中对大量人群进行肾结石疾病的病因和病程研究提供了独特的机会和资源，并收集了数据和样本。
