Sun Yu, Kan Ze, Zhang Zi-Feng, Song Li, Jiang Chao, Wang Ji, Ma Wan-Li, Li Yi-Fan, Wang Li, Liu Li-Yan
International Joint Research Center for Persistent Toxic Substances (IJRC-PTS)/International Joint Research Center for Arctic Environment and Ecosystem (IJRC-AEE), State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin, 150090, China; School of Environment, Harbin Institute of Technology, Harbin, 150090, China.
Heilongjiang Institute of Labor Hygiene and Occupational Diseases/The Second Hospital of Heilongjiang Province, Harbin, 150028, China.
Environ Pollut. 2023 Apr 15;323:121266. doi: 10.1016/j.envpol.2023.121266. Epub 2023 Feb 11.
Elevated urinary polycyclic aromatic hydrocarbon metabolites have been linked to an increased risk of cardiovascular diseases (CVDs). However, for petrochemical workers with potentially high PAH exposure, it remains largely unknown whether the link will be amplified. Thus, this work aimed to investigate 14 urinary mono-hydroxylated polycyclic aromatic hydrocarbons (OH-PAHs) in 746 petrochemical workers working in a Chinese petrochemical industrial area and their association with the risk of hypertension using the binary logistic regression. Metabolites of naphthalene, fluorene, phenanthrene, and pyrene were frequently detected in the 746 urine samples analyzed (>98%), with ΣOH-PAH concentration in the range of 0.906-358 ng/mL. 2-hydroxynaphthalene accounted for the largest proportion of ten detected OH-PAHs (60.8% of ΣOH-PAHs). There were significant correlations between these metabolites and other factors, including gender, age, and body mass index. Diastolic blood pressure, not systolic blood pressure, was significant positively associated with the urinary ΣOH-PAH concentrations of the petrochemical workers. Elevated urinary 2/3-OH-Flu was significantly associated with an increased risk of hypertension (adjusted odds ratio: 1.96, 95% confidence interval: 1.20-3.18, p = 0.007), suggesting that PAH exposure in petrochemical workers was a driving factor of hypertension. In the stratified analysis, the association was more pronounced in those who were overweight with older age. Although the PAH exposure risk in petrochemical workers based on the estimated daily intakes was relatively low. Given the long-term impact, we call attention to CVDs of petrochemical workers.
尿中多环芳烃代谢物水平升高与心血管疾病（CVD）风险增加有关。然而，对于可能高暴露于多环芳烃的石化工人来说，这种关联是否会增强在很大程度上仍不清楚。因此，本研究旨在调查中国某石化工业区746名石化工人尿中的14种单羟基多环芳烃（OH-PAHs），并采用二元逻辑回归分析它们与高血压风险的关系。在所分析的746份尿样中，萘、芴、菲和芘的代谢物检出率较高（>98%），ΣOH-PAH浓度范围为0.906 - 358 ng/mL。2-羟基萘在检测到的10种OH-PAHs中占比最大（占ΣOH-PAHs的60.8%）。这些代谢物与性别、年龄和体重指数等其他因素之间存在显著相关性。石化工人的舒张压而非收缩压与尿中ΣOH-PAH浓度呈显著正相关。尿中2/3-OH-Flu升高与高血压风险增加显著相关（调整后的比值比：1.96，95%置信区间：1.20 - 3.18，p = 0.007），表明石化工人接触多环芳烃是高血压的一个驱动因素。在分层分析中，这种关联在超重且年龄较大的人群中更为明显。尽管根据估计的每日摄入量，石化工人接触多环芳烃的风险相对较低。考虑到长期影响，我们呼吁关注石化工人的心血管疾病。
