Reinecke P, Frenzel H, Hort W, Willberg B
Pathologisches Institut der Universität Düsseldorf.
Dtsch Med Wochenschr. 1987 Dec 4;112(49):1902-5. doi: 10.1055/s-2008-1068351.
In 1980, a then 7-year-old boy from Yugoslavia had an atrial myxoma removed. Since then there have been no abnormal cardiac signs or symptoms. Between 1982 and 1986 five cutaneous myxomas in the trunk region were removed. None of the tumours had histological signs of malignancy. These observations can be fitted into the symptom complex (described in 1985 by Carney et al.) of cardiac myxoma, cutaneous myxoma, changes in skin pigmentation, and abnormal endocrine functions--although not all signs need be present together. A disposition towards the development of myxomatous tumours is to be assumed in these patients. One should, therefore, always suspect an occult cardiac myxoma in the presence of multiple cutaneous myxomas. Appropriate diagnostic measures need to be taken before the typical and sometimes lethal consequences of a cardiac myxoma have occurred.
1980年，一名当时7岁的南斯拉夫男孩接受了心房黏液瘤切除手术。从那时起，他没有出现任何异常的心脏体征或症状。1982年至1986年间，其躯干区域的5个皮肤黏液瘤被切除。这些肿瘤均无恶性组织学特征。这些观察结果符合（卡尼等人于1985年描述的）心脏黏液瘤、皮肤黏液瘤、皮肤色素沉着变化及内分泌功能异常的症状复合体——尽管并非所有体征都需同时出现。推测这些患者有发生黏液瘤性肿瘤的倾向。因此，在出现多发性皮肤黏液瘤时，应始终怀疑存在隐匿性心脏黏液瘤。在心脏黏液瘤出现典型且有时致命的后果之前，需要采取适当的诊断措施。
