[A low molecular-weight angiogenesis factor isolated from Lewis lung carcinoma].

A fraction with the angiogenetic activity was obtained by the methods of the gel-chromatography on G-100 and the ion-exchange chromatography on DEAE-cellulose. Treatment of this fraction with the 10% water isopropanol solution has led to dissociation of the obtained material with a release of a low-molecular-weight angiogenic factor with a high angiogenic activity when tested on the chorioallantoic membrane. The molecular weight of this factor (300-600 daltons) was estimated by the chromatography on the biogel P2.