Mimori T, Tanaka M, Tada I
Department of Parasitic Diseases, Kumamoto University Medical School, Japan.
Exp Parasitol. 1987 Dec;64(3):342-6. doi: 10.1016/0014-4894(87)90045-2.
Formation of a marked protective immunity against the challenge infection was found in the rats immunized with excretory/secretory (ES) products of Strongyloides ratti adult worms. Immunization by intraduodenal injection of ES products reduced both the fecal egg counts and the adult worm burden by subcutaneous inoculation of infective larvae and by an intraduodenal implantation. The duration of parasitism in the immunized rats, however, was not shortened compared with that of control rats. The normal migration of subcutaneously challenged larvae was not affected by ES product immunization. Intestinal mastocytosis occurred according to the appearance of adult worms in the small intestine of the immunized rats earlier than it did in controls. This result suggests that mastocytosis is involved in the induction of protection by ES products of S. ratti adult worms.
在用鼠类圆线虫成虫的排泄/分泌（ES）产物免疫的大鼠中，发现针对攻击感染形成了显著的保护性免疫。通过十二指肠内注射ES产物进行免疫，可减少经皮下接种感染性幼虫和十二指肠内植入后的粪卵计数及成虫负荷。然而，与对照大鼠相比，免疫大鼠的寄生持续时间并未缩短。ES产物免疫并未影响皮下攻击的幼虫的正常迁移。免疫大鼠小肠中肥大细胞增多症的发生早于对照组，这是根据成虫的出现情况得出的。该结果表明，肥大细胞增多症参与了鼠类圆线虫成虫ES产物诱导的保护作用。
