Korenaga M, Nawa Y, Mimori T, Tada I
J Parasitol. 1983 Feb;69(1):78-82.
Generation of intestinal immunity by antigenic stimulation with preintestinal, tissue-migrating larvae was investigated in the Strongyloides ratti-rat model. The results of daily fecal egg counts showed that the intestinal immunity against adult worms could be partially generated by priming with preintestinal migrating larvae. A further study demonstrated that this partial reduction of daily fecal egg count was mainly the result of inhibitory effects on the fecundity of the parasitic females, although the expulsion of the parasite from the gut could be advanced by several days. After tertiary immunization with preintestinal larvae, no significant potentiation in the protection was observed when compared with the rats treated by primary immunization alone.
在大鼠类圆线虫-大鼠模型中，研究了用肠前组织迁移幼虫进行抗原刺激产生肠道免疫的情况。每日粪便虫卵计数结果表明，用肠前迁移幼虫进行预激发可部分产生针对成虫的肠道免疫。进一步的研究表明，每日粪便虫卵计数的这种部分减少主要是对寄生雌虫繁殖力的抑制作用的结果，尽管寄生虫从肠道排出可提前几天。与仅接受初次免疫的大鼠相比，用肠前幼虫进行三次免疫后，未观察到保护作用有明显增强。
