Langley R J, Gray J S
Department of Agricultural Zoology and Genetics, University College, Belfield, Dublin, Ireland.
Exp Parasitol. 1987 Dec;64(3):466-73. doi: 10.1016/0014-4894(87)90061-0.
Immature gerbils (4 weeks of age or less) proved to be more resistant to Babesia divergens infections than did mature animals (greater than 8 weeks old). Nutritional studies showed that a milk diet contributes little to this innate resistance. Similarly, the apparent predilection of B. divergens for mature erythrocytes, and also in vitro serum incubation studies, suggested that blood factors do not contribute to any major degree. Splenectomy of immature gerbils abolished their nonspecific resistance and studies with splenocyte incubations with the piroplasm imply that splenic integrity is necessary for the maintenance of this, apparently antibody-independent, resistance to infection with B. divergens.
事实证明，未成熟的沙鼠（4周龄及以下）比成熟动物（8周龄以上）对分歧巴贝斯虫感染更具抵抗力。营养研究表明，以牛奶为食对这种先天抵抗力贡献不大。同样，分歧巴贝斯虫对成熟红细胞的明显偏好以及体外血清孵育研究表明，血液因素在很大程度上不起作用。未成熟沙鼠的脾切除术消除了它们的非特异性抵抗力，并且对脾细胞与梨形虫进行孵育的研究表明，脾脏的完整性对于维持这种显然不依赖抗体的对分歧巴贝斯虫感染的抵抗力是必要的。
