Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
Department of Neurology and Clinical Neurophysiology, St. Olavs Hospital, Trondheim, Norway.
Cephalalgia. 2023 Mar;43(3):3331024221148398. doi: 10.1177/03331024221148398.
Migraine has a largely unexplained connection with sleep and is possibly related to a dysfunction of thalamocortical systems and cortical inhibition. In this study we investigate the effect of insufficient sleep on cortical sensorimotor processing in migraine.
We recorded electroencephalography during a sensorimotor task from 46 interictal migraineurs and 28 controls after two nights of eight-hour habitual sleep and after two nights of four-hour restricted sleep. We compared changes in beta oscillations of the sensorimotor cortex after the two sleep conditions between migraineurs, controls and subgroups differentiating migraine subjects usually having attacks starting during sleep and not during sleep. We included preictal and postictal recordings in a secondary analysis of temporal changes in relation to attacks.
Interictally, we discovered lower beta synchronisation after sleep restriction in sleep related migraine compared to non-sleep related migraine (p=0.006) and controls (p=0.01). No differences were seen between controls and the total migraine group in the interictal phase. After migraine attacks, we observed lower beta synchronisation (p<0.001) and higher beta desynchronisation (p=0.002) after sleep restriction closer to the end of the attack compared to later after the attack.
The subgroup with sleep related migraine had lower sensorimotor beta synchronisation after sleep restriction, possibly related to dysfunctional GABAergic inhibitory systems. Sufficient sleep during or immediately after migraine attacks may be of importance for maintaining normal cortical excitability.
偏头痛与睡眠之间存在着很大程度上尚未得到解释的联系，可能与丘脑皮质系统和皮质抑制功能障碍有关。在这项研究中，我们研究了睡眠不足对偏头痛患者皮质感觉运动处理的影响。
我们在睡眠剥夺前后两晚分别记录了 46 名间歇期偏头痛患者和 28 名对照者进行感觉运动任务时的脑电图。我们比较了偏头痛患者、对照组以及偏头痛亚组（偏头痛患者通常在睡眠中或不在睡眠中开始发作）在两种睡眠条件下感觉运动皮质β振荡的变化。我们将发作前和发作后的记录纳入与发作相关的时间变化的二次分析。
在间歇期，与非睡眠相关偏头痛（p=0.01）和对照组（p=0.01）相比，睡眠相关偏头痛患者在睡眠限制后β同步性降低（p=0.006）。在间歇期，对照组和偏头痛总组之间没有差异。在偏头痛发作后，我们观察到睡眠限制后β同步性降低（p<0.001）和β去同步性增加（p=0.002），与发作结束时相比，发作后更晚时更明显。
与睡眠相关的偏头痛亚组在睡眠限制后感觉运动β同步性降低，可能与 GABA 能抑制系统功能障碍有关。在偏头痛发作期间或之后立即获得充足的睡眠可能对维持正常皮质兴奋性很重要。
