Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Russia.
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
Dokl Biochem Biophys. 2022 Dec;507(1):330-333. doi: 10.1134/S1607672922340038. Epub 2023 Feb 14.
Development of combined schemes for the treatment of oncological diseases is a promising strategy to improve the effectiveness of antitumor therapy. This paper shows the fundamental possibility of multiplying the antitumor effect by combining targeted and photodynamic therapy. It was demonstrated that sequential treatment of HER-2 positive breast cancer cells with the targeted toxin DARPin-LoPE and the photoactive compound photodithazine leads to a synergistic enhancement of their effect. In the future, this approach is intended to achieve the maximum therapeutic effect while minimizing the risks of negative side effects.
联合方案治疗肿瘤疾病的开发是提高抗肿瘤治疗效果的有前途的策略。本文表明，通过结合靶向和光动力疗法，可以使抗肿瘤效果倍增。研究表明，用靶向毒素 DARPin-LoPE 和光活性化合物光蝶嗪对 HER-2 阳性乳腺癌细胞进行序贯治疗，可协同增强其疗效。未来，这种方法旨在在最大程度地提高治疗效果的同时，将负面副作用的风险降到最低。
