Engineering Research Centre of Pharmaceutical Process Chemistry, Ministry of Education, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China.
J Org Chem. 2023 Mar 3;88(5):2942-2951. doi: 10.1021/acs.joc.2c02676. Epub 2023 Feb 14.
An iridium catalytic system with a ferrocene-based phosphine ligand bearing a modular and tunable unsymmetrical vicinal diamine scaffold was developed for the asymmetric hydrogenation of aryl ketones. This approach provided a powerful tool for the enantioselective synthesis of diverse chiral alcohols with excellent reactivity and enantioselectivity (up to 99% yield, up to 99% ee, and up to 50,000 turnover number). The substituents and chirality of unsymmetrical diamines in ligands played an important role in the satisfactory results.
开发了一种基于二茂铁的膦配体的铱催化体系，该配体带有模块化和可调谐的非对称邻位二胺支架，用于芳基酮的不对称氢化。该方法为各种手性醇的对映选择性合成提供了有力工具，具有出色的反应性和对映选择性（高达 99%的产率、高达 99%的对映体过量和高达 50,000 的周转数）。配体中不对称二胺的取代基和手性对满意的结果起着重要作用。
