华氏巨球蛋白血症在浆细胞骨髓瘤维持治疗期间发生。
Waldenstrom Macroglobulinemia Arising During Maintenance Therapy of Plasma Cell Myeloma.
出版信息
Clin Lab. 2023 Feb 1;69(2). doi: 10.7754/Clin.Lab.2022.220527.
BACKGROUND
Both plasma cell myeloma (PCM) and Waldenstrom's macroglobulinemia (WM) are mature B-cell neoplasms commonly involving bone marrow and usually related to paraproteinemia.
METHODS
Secondary WM in a patient with PCM during maintenance therapy has not been previously reported. We herein report the first case of WM arising during maintenance therapy of PCM.
RESULTS
The diagnosis of secondary WM during maintenance therapy of PCM was based on combination of medical history, morphology, flow cytometry, immunofixation electrophoresis, and molecular genetics.
CONCLUSIONS
This case highlights the importance of an integrated diagnostic work-up, with an interesting role for morphology and flow immunotyping.
背景
浆细胞骨髓瘤（PCM）和华氏巨球蛋白血症（WM）均为成熟 B 细胞肿瘤，常累及骨髓，通常与副蛋白血症有关。
方法
PCM 患者在维持治疗期间发生继发性 WM 此前尚未有报道。我们在此报告首例 PCM 维持治疗期间发生 WM。
结果
PCM 维持治疗期间发生继发性 WM 的诊断基于病史、形态学、流式细胞术、免疫固定电泳和分子遗传学的综合分析。
结论
该病例强调了综合诊断性检查的重要性，形态学和流式免疫分型具有重要作用。
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