合成一系列具有唾液酸 α2-3 乳糖部分连接更长间隔臂的糖聚物。
Synthetic assembly of a series of glycopolymers having sialyl α2-3 lactose moieties connected with longer spacer arms.
机构信息
Area for Molecular Function, Division of Material Science, Graduate School of Science and Engineering, Saitama University, Sakura, Saitama 338-8570, Japan.
Area for Molecular Function, Division of Material Science, Graduate School of Science and Engineering, Saitama University, Sakura, Saitama 338-8570, Japan; Medical Innovation Research Unit (MiU), Advanced Institute of Innovative Technology (AIIT), Saitama University, Sakura, Saitama 338-8570, Japan; Area for Health Science, Strategic Research Center, Saitama University, Sakura, Saitama 338-8570, Japan.
出版信息
Bioorg Med Chem. 2023 Mar 1;81:117209. doi: 10.1016/j.bmc.2023.117209. Epub 2023 Feb 9.
Glycopolymers having sialyl α2-3 lactose moieties via longer spacer arms were systematically prepared from the corresponding glycomonomers. Radical polymerization of glycomonomers gave a series of glycopolymers displaying various sugar densities. Fluorometric analyses of wheat germ agglutinin (WGA) against the glycopolymers were conducted and the results showed unique binding specificities on the basis of sugar densities.
通过较长的间隔臂将具有唾液酸α2-3 乳糖部分的糖聚合物有系统地从相应的糖单体制备。糖单体的自由基聚合得到了一系列显示各种糖密度的糖聚合物。对糖聚合物进行了麦胚凝集素（WGA）的荧光分析，结果表明基于糖密度具有独特的结合特异性。
Zotero 插件