School of Nursing, Jilin University, Changchun, 130021, Jilin, China.
The First Hospital of Jilin University, Changchun, 130021, Jilin, China.
BMC Musculoskelet Disord. 2023 Feb 14;24(1):124. doi: 10.1186/s12891-023-06186-3.
The purpose of this study was to explore the effects of nanoparticles on gouty arthritis, and to provide evidence for the preclinical application of nanoparticles in gouty arthritis and ideas for nanomedicine improvement for nanoparticle researchers.
Five databases including the Cochrane Library, PubMed, Scopus, Web of Science, and Embase were searched for eligible studies until April 2022. The quality of the selected studies was assessed by SYRCLE's risk of bias (RoB) tool, and the random-effects model was used to calculate the overall effect sizes of weighted mean differences (WMD).
Ten studies met the inclusion criteria. Results showed that nanoparticles were effective in reducing uric acid levels (WMD: -4.91; 95% confidence interval (CI): - 5.41 to - 4.41; p < 0.001), but were not better than allopurinol (WMD: -0.20; 95% CI: - 0.42 to 0.02; p = 0.099). It was worth noting that the nanoparticles were safer than allopurinol. Subgroup analyses indicated that nanoparticle encapsulated substance, animal species, nanoparticle dosage, animal quantity, and animal gender were all sources of heterogeneity.
The nanoparticles are safe medications for gouty arthritis which can effectively reduce uric acid levels in rodents. Although the results are still uncertain, it is expected to have certain clinical application value. The nanoparticles may be the preclinical medications for gouty arthritis in the future.
本研究旨在探讨纳米粒子对痛风性关节炎的影响，为纳米粒子在痛风性关节炎的临床前应用提供依据，并为纳米医学的改进提供思路。
检索 Cochrane 图书馆、PubMed、Scopus、Web of Science 和 Embase 等五个数据库，截至 2022 年 4 月，筛选出符合条件的研究。采用 SYRCLE 的偏倚风险（RoB）工具评估纳入研究的质量，并采用随机效应模型计算加权均数差（WMD）的总效应大小。
共有 10 项研究符合纳入标准。结果表明，纳米粒子在降低血尿酸水平方面有效（WMD：-4.91；95%置信区间（CI）：-5.41 至-4.41；p<0.001），但不如别嘌醇（WMD：-0.20；95% CI：-0.42 至 0.02；p=0.099）。值得注意的是，纳米粒子比别嘌醇更安全。亚组分析表明，纳米粒子包裹的物质、动物种类、纳米粒子剂量、动物数量和动物性别均为异质性来源。
纳米粒子是治疗痛风性关节炎的安全药物，可有效降低啮齿动物的血尿酸水平。虽然结果仍不确定，但有望具有一定的临床应用价值。纳米粒子可能是未来痛风性关节炎的临床前药物。
