Pediatric Poison Control Centre, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Pediatric Intensive Care Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Ital J Pediatr. 2023 Feb 14;49(1):20. doi: 10.1186/s13052-023-01427-6.
This study aimed to analyze all the patients who contacted the hospital's pediatric poison control center (PPCC) for exposure to ibuprofen and acetaminophen, in order to assess the incidence of any adverse reactions.
We retrospectively reported the clinical data of children who accessed the PPCC of the Bambino Gesù Children's Hospital, IRCCS, Rome, from January 1, 2018 to September 30, 2022 due to wrong, accidental or intentional intake of inappropriate doses of acetaminophen and/or ibuprofen. In addition, we compared patients according to the intake of one of the two drugs and reported the trimestral distribution of cases during the study period.
A total of 351 patients accessed the PPCC during the study period. The median age was 3.0 years. Most patients were females (57.8%). The most common reason for inappropriate oral intake of paracetamol or ibuprofen was a wrong use or an accidental intake (78.6%), with a fifth of patients taking the drug with suicidal intent (21.1%). According to the PPCC evaluation, most patients were not intoxicated (70.4%). Hospitalization was required for 30.5% of patients. Adverse reactions were reported in 10.5% of cases, with a similar incidence in patients who took paracetamol or ibuprofen. Nausea and vomiting were the most commonly reported adverse reactions. A higher frequency of moderate intoxication was found in patients who took paracetamol compared to ibuprofen (p = 0.001). The likelihood of intoxication was also higher in the paracetamol cohort. A spike of cases was registered at the end of 2021.
We analyze exposures to the two most commonly used pediatric molecules, paracetamol and ibuprofen, to assess the frequency of adverse reactions. We demonstrated that these relatively "safe" drugs may be associated with intoxications and adverse reactions when inappropriately administered.
本研究旨在分析所有因接触布洛芬和对乙酰氨基酚而联系医院儿科中毒控制中心（PPCC）的患者，以评估是否存在任何不良反应。
我们回顾性报告了 2018 年 1 月 1 日至 2022 年 9 月 30 日期间，因错误、意外或故意摄入不适当剂量的对乙酰氨基酚和/或布洛芬而访问罗马 Bambino Gesù 儿童医院儿科中毒控制中心（IRCCS）的儿童的临床数据。此外，我们根据摄入其中一种药物的情况对患者进行了比较，并报告了研究期间各季度的病例分布情况。
在研究期间，共有 351 名患者访问了 PPCC。中位年龄为 3.0 岁。大多数患者为女性（57.8%）。最常见的不适当口服对乙酰氨基酚或布洛芬的原因是错误使用或意外摄入（78.6%），其中五分之一的患者有自杀意图（21.1%）。根据 PPCC 的评估，大多数患者没有中毒（70.4%）。需要住院治疗的患者占 30.5%。报告了 10.5%的不良反应病例，服用对乙酰氨基酚或布洛芬的患者发生率相似。最常见的不良反应是恶心和呕吐。与服用布洛芬的患者相比，服用对乙酰氨基酚的患者中度中毒的频率更高（p=0.001）。对乙酰氨基酚组中毒的可能性也更高。2021 年底登记了一波病例高峰。
我们分析了两种最常用的儿科药物（对乙酰氨基酚和布洛芬）的暴露情况，以评估不良反应的频率。我们证明，这些相对“安全”的药物在不适当使用时可能与中毒和不良反应有关。
