Department of Chemistry, Quaid-i-Azam University, Islamabad-45320, Pakistan.
Department of Basic and Applied Chemistry, Faculty of Science and Technology, University of Central Punjab, Lahore-54590, Pakistan.
Mini Rev Med Chem. 2023;23(10):1079-1089. doi: 10.2174/1389557523666230213140641.
It is estimated that viral infections contribute 15-20% of all human cancers. Several types of human papillomaviruse (HPV) are related to the development of many cancer types and their treatment. About 200 HPV viruses have been identified, and each type of virus is integrated with a certain type of clinical lesions affecting the areas of skin and mucous membranes. Infections associated with HPV are known to cause multiple cancer types such as uterine cancer, cervical, vaginal carcinoma, and other varieties of carcinomas such as genital and oropharyngeal, penile, and short-lived carcinomas. Most of the HPV types are considered as high-risk mutants that can provoke cervical cancer in females in addition to significant contribution to other cancer types such as anogenital cancer and tumor in head and neck regions. Among them, high risk human papilloma viruses (HR-HPV) subtypes 16 and 18 play a major role in the etiology of cervical cancer worldwide. Although, cervical cancer incidence and fatality rates vary greatly depending on geographical area, it is the leading cause of mortality in women around the world. In addition, it is epidemiologically similar to a sexually transmitted disease of low infectivity. In this review article, the association of HPV with different types of cancers have been explained, but the main focus remains on cervical cancer.
据估计，病毒感染导致了 15%至 20%的人类癌症。多种类型的人乳头瘤病毒（HPV）与许多癌症类型的发展及其治疗有关。目前已鉴定出约 200 种 HPV 病毒，每种病毒都与一定类型的临床病变有关，影响皮肤和黏膜区域。已知与 HPV 相关的感染会导致多种癌症类型，如子宫癌、宫颈癌、阴道癌以及其他种类的癌症，如生殖器和口咽癌、阴茎癌和短暂性癌。大多数 HPV 类型被认为是高危突变体，除了对其他癌症类型（如肛门生殖器癌和头颈部肿瘤）有重要贡献外，还能在女性中引发宫颈癌。其中，高危型人乳头瘤病毒（HR-HPV）亚型 16 和 18 在全球范围内对宫颈癌的病因学起着重要作用。尽管宫颈癌的发病率和死亡率因地理位置而异，但它仍是全球女性死亡的主要原因。此外，它在流行病学上类似于低传染性的性传播疾病。在这篇综述文章中，解释了 HPV 与不同类型癌症的关联，但主要重点仍放在宫颈癌上。
