Gupta Mayank, Gupta Nihit, Madabushi Jayakrishna
Child and Adolescent Psychiatry, Southwood Psychiatric Hospital, Pittsburgh, USA.
Psychiatry, Dayton Children's Hospital, Dayton, USA.
Cureus. 2023 Jan 13;15(1):e33745. doi: 10.7759/cureus.33745. eCollection 2023 Jan.
Cyproheptadine is a widely prescribed first-generation antihistamine, and due to its unique chemical structure, it has a popular off-label choice for a range of clinical conditions. Its efficacy is widely debated in the literature, but there are reports of hepatotoxicity as a rare adverse effect. Its benefits in migraine prophylaxis and appetite stimulation also underscore a highly overlapping clinical pathway that requires additional assessment and evaluation. The evidence suggests a baseline metabolic profile before initiation and assessment for co-occurring mental health conditions may improve overall response with evidence-based mental health interventions.
赛庚啶是一种广泛使用的第一代抗组胺药，由于其独特的化学结构，它在一系列临床病症中是一种常用的非标签用药选择。其疗效在文献中存在广泛争议，但有报告称肝毒性是一种罕见的不良反应。它在偏头痛预防和食欲刺激方面的益处也凸显了一条高度重叠的临床路径，这需要进行额外的评估和评价。有证据表明，在开始治疗前进行基线代谢评估以及对同时存在的心理健康状况进行评估，可能会通过基于证据的心理健康干预措施改善总体反应。
