Chem. Pharm. Sc. Dept., University of Trieste, Via Giorgieri 1, 34127 Trieste, Italy.
Life Sc. Dept., University of Trieste, Via Weiss 2, 34128 Trieste, Italy.
J Mater Chem B. 2023 Jun 21;11(24):5378-5389. doi: 10.1039/d2tb02643k.
Dipeptides are attractive building blocks for biomaterials in light of their inherent biocompatibility, biodegradability, and simplicity of preparation. Since the discovery of diphenylalanine (Phe-Phe) self-assembling ability into nanotubes, research efforts have been devoted towards the identification of other dipeptide sequences capable of forming these interesting nanomorphologies, although design rules towards nanotube formation are still elusive. In this review, we analyze the dipeptide sequences reported thus far for their ability to form nanotubes, which often feature water-filled supramolecular channels as revealed by single-crystal X-ray diffraction, as well as their properties, and their potential biological applications, which span from drug delivery and regenerative medicine, to bioelectronics and bioimaging.
二肽因其固有生物相容性、可生物降解性和制备简单性，成为生物材料有吸引力的构建模块。自从发现二苯丙氨酸（Phe-Phe）自组装成纳米管的能力以来，研究人员一直致力于寻找其他能够形成这些有趣纳米形态的二肽序列，尽管形成纳米管的设计规则仍然难以捉摸。在这篇综述中，我们分析了迄今为止报道的能够形成纳米管的二肽序列，这些纳米管通常具有由单晶 X 射线衍射揭示的充满水的超分子通道，以及它们的性质和潜在的生物应用，涵盖了从药物输送和再生医学到生物电子学和生物成像。
