Keranov Stanislav, Widmann Laila, Jafari Leili, Liebetrau Christoph, Keller Till, Troidl Christian, Kriechbaum Steffen, Voss Sandra, Bauer Pascal, Richter Manuel J, Tello Khodr, Gall Henning, Ghofrani Hossein A, Wiedenroth Christoph B, Guth Stefan, Seeger Werner, Hamm Christian W, Nef Holger, Dörr Oliver
Department of Cardiology & Angiology, University of Giessen, Giessen, 35392, Germany.
German Center for Cardiovascular Research (DZHK), Partner Site RheinMain, Bad Nauheim, 61231, Germany.
Biomark Med. 2022 Dec;16(17):1193-1207. doi: 10.2217/bmm-2022-0395. Epub 2023 Feb 15.
This study analyzed the utility of soluble ST2 (sST2) and GDF-15 as biomarkers of right ventricular (RV) function in patients with pulmonary hypertension (PH). GDF-15 and sST2 serum concentrations were measured in patients with PH (n = 628), dilated cardiomyopathy (n = 31) and left ventricular hypertrophy (n = 47), and in healthy controls (n = 61). Median sST2 and GDF-15 levels in patients with left ventricular hypertrophy were higher than in patients with PH and dilated cardiomyopathy. In tertile analysis GDF-15 >1363 pg/ml and sST2 >38 ng/ml were associated with higher N-terminal pro-brain natriuretic peptide, RV systolic dysfunction, RV-pulmonary arterial uncoupling and hemodynamic impairment. GDF-15 and sST2 are potential biomarkers of RV dysfunction in patients with PH.
本研究分析了可溶性ST2（sST2）和生长分化因子15（GDF-15）作为肺动脉高压（PH）患者右心室（RV）功能生物标志物的效用。对PH患者（n = 628）、扩张型心肌病患者（n = 31）和左心室肥厚患者（n = 47）以及健康对照者（n = 61）测量了GDF-15和sST2血清浓度。左心室肥厚患者的sST2和GDF-15中位数水平高于PH患者和扩张型心肌病患者。在三分位数分析中，GDF-15>1363 pg/ml和sST2>38 ng/ml与较高的N末端脑钠肽前体、RV收缩功能障碍、RV-肺动脉解偶联和血流动力学损害相关。GDF-15和sST2是PH患者RV功能障碍的潜在生物标志物。
