Mathematical Institute, University of Leipzig, Augustusplatz 10, D-04109, Leipzig, Germany.
Institute for Analysis and Numerics, University of Münster, Einsteinstr. 62, D-48149, Münster, Germany.
J Math Biol. 2023 Feb 15;86(3):45. doi: 10.1007/s00285-023-01881-0.
In this paper we deal with two aspects of the Covid epidemic. The first is a phase change during the epidemic. The empirical observation is that once a certain threshold of active infections is reached, the rate of infection is increasing significantly. This threshold depends, among others, also on the season. We model this phenomenon as a jump in the coefficient of the virus exposition, giving the force of infection. In a chemical mass action law this coefficient corresponds to the reaction rate. We get a free boundary problem in time, which exhibits deterministic 'metastability'. In a population which is in a state of herd immunity, still, if the number of imported infections is large enough, an epidemic wave can start. The second aspect is the two scale nature of the infection network. On one hand side, there is always a finite number of reoccuring-deterministic-contacts, and on the other hand there is a large number of possible random contacts. We present a simple example, where the group size of deterministic contacts is two, and the graph of random contacts is complete.
本文主要讨论了新冠疫情的两个方面。首先,我们研究了疫情期间的相变现象。经验观察表明,一旦感染数量达到某个特定的阈值,感染率就会显著增加。这个阈值取决于季节等多种因素。我们将这种现象建模为病毒暴露系数的跳跃,即感染力度的增加。在化学反应的质量作用定律中,这个系数对应着反应速率。因此,我们得到了一个具有时间依赖性的自由边界问题,其中存在确定性的“亚稳定性”。在具有群体免疫力的人群中,如果输入性感染数量足够大,仍然可能引发疫情波。第二个方面是感染网络的双重尺度性质。一方面,始终存在有限数量的重复确定性接触,另一方面,也存在大量可能的随机接触。我们给出了一个简单的例子,其中确定性接触的群体大小为两个,而随机接触的图是完全图。