Li Siqi, Huang Qiong, He Baimei
Department of Geriatric Respiratory and Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, 410008, China.
Department of Geriatric Medicine, Xiangya Hospital, Central South University, Changsha, 410008, China.
Lung. 2023 Apr;201(2):201-215. doi: 10.1007/s00408-023-00607-9. Epub 2023 Feb 15.
Chronic obstructive pulmonary disease (COPD) is a common, preventable, and treatable disease characterized by irreversible airflow obstruction and lung function decline. It is well established that COPD represents a major cause of morbidity and mortality globally. Due to the substantial economic and social burdens associated with COPD, it is necessary to discover new targets and develop novel beneficial therapies. Although the pathogenesis of COPD is complex and remains to be robustly elucidated, numerous studies have shown that oxidative stress, inflammatory responses, cell apoptosis, autophagy, and aging are involved in the pathogenesis of COPD. Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase belonging to the silent information regulator 2 (Sir2) family. Multiple studies have indicated that SIRT1 plays an important role in oxidative stress, apoptosis, inflammation, autophagy, and cellular senescence, which contributes to the pathogenesis and development of COPD. This review aimed to discuss the functions and mechanisms of SIRT1 in the progression of COPD and concluded that SIRT1 activation might be a potential therapeutic strategy for COPD.
慢性阻塞性肺疾病（COPD）是一种常见的、可预防和可治疗的疾病，其特征为不可逆的气流阻塞和肺功能下降。众所周知，COPD是全球发病和死亡的主要原因之一。由于COPD带来巨大的经济和社会负担，有必要发现新的靶点并开发新的有效治疗方法。尽管COPD的发病机制复杂且仍有待充分阐明，但大量研究表明，氧化应激、炎症反应、细胞凋亡、自噬和衰老均参与了COPD的发病过程。沉默信息调节因子1（SIRT1）是一种烟酰胺腺嘌呤二核苷酸（NAD+）依赖性脱乙酰酶，属于沉默信息调节因子2（Sir2）家族。多项研究表明，SIRT1在氧化应激、细胞凋亡、炎症、自噬和细胞衰老中起重要作用，这对COPD的发病机制和发展有影响。本综述旨在探讨SIRT1在COPD进展中的功能和机制，并得出结论：激活SIRT1可能是COPD的一种潜在治疗策略。
