Department of Nuclear Medicine, Medical Faculty, Ankara University Medical School, Ankara, Turkey.
Department of Pathology, Ankara University Medical School, Ankara, Turkey.
Eur Arch Otorhinolaryngol. 2023 Jun;280(6):2905-2910. doi: 10.1007/s00405-023-07870-9. Epub 2023 Feb 15.
To investigate the relationship between cell content and histopathological features of parathyroid lesions and 18F-FCH uptake intensity on PET/CT images.
Patients with primary hyperparathyroidism (age > 18) who were referred to 18F-FCH PET/CT were involved. All patients underwent parathyroidectomy. Correlation of SUVmax with following factors were statistically analysed: serum PTH, Ca, P levels and histopathological parameters, total absolute amounts of chief cell, oxyphyllic cell and clear cell components calculated by the multiplication of the volume of the parathyroid lesion and the percentage of each type of cell content (called as Absolute, Absolute and Absolute reflecting the total amount of each cell group).
A total of 34 samples from 34 patients (6M, 28F, mean age: 53.32 ± 15.15, min: 14, max: 84) who had a positive 18F-FCH PET/CT localizing at least one parathyroid lesion were involved. In the whole study group, SUVmax was found to be correlated with the greatest diameter and volume of the lesion and Absolute (p = 0.004, p = 0.002 and p = 0.035, respectively). In the subgroup analysis of 28 samples with longest diameter > 1 cm, the correlation between SUVmax and Absolute remained significant (p = 0.036) and correlation between SUVmax and volume and longest diameter became stronger (p = 0.011 and p > 0.001, respectively). No correlation was found between SUVmax and Absolute or Absolute.
There might be a relationship between 18F-FCH uptake intensity and chief cell content in patients with parathyroid adenoma. Further studies with larger patient groups would be beneficial to support the data.
研究甲状旁腺病变的细胞含量与组织病理学特征以及 PET/CT 图像上 18F-FCH 摄取强度之间的关系。
纳入因原发性甲状旁腺功能亢进（年龄＞18 岁）而接受 18F-FCH PET/CT 检查的患者。所有患者均接受甲状旁腺切除术。统计分析 SUVmax 与以下因素的相关性：血清 PTH、Ca、P 水平和组织病理学参数，通过将甲状旁腺病变的体积乘以每种细胞含量的百分比来计算主细胞、嗜酸性细胞和透明细胞成分的总绝对量（称为 Absolute、Absolute 和 Absolute，反映每个细胞群的总含量）。
共纳入 34 例 34 名患者（6 名男性，28 名女性，平均年龄：53.32±15.15 岁，年龄范围 14 岁至 84 岁）的 34 个样本，这些患者的 18F-FCH PET/CT 均显示至少有一个甲状旁腺病变呈阳性定位。在整个研究组中，SUVmax 与病变的最大直径和体积以及 Absolute 呈正相关（p=0.004、p=0.002 和 p=0.035）。在最长直径＞1cm 的 28 个样本的亚组分析中，SUVmax 与 Absolute 之间的相关性仍然显著（p=0.036），SUVmax 与体积和最长直径之间的相关性也增强（p=0.011 和 p＞0.001）。SUVmax 与 Absolute 或 Absolute 之间无相关性。
在甲状旁腺腺瘤患者中，18F-FCH 摄取强度与主细胞含量之间可能存在一定关系。进一步的大样本量研究将有助于支持这一数据。
