机器灌注如何改善肝脏缺血再灌注损伤。
How Machine Perfusion Ameliorates Hepatic Ischaemia Reperfusion Injury.
机构信息
Liver Unit, Queen Elizabeth Hospital Birmingham, Birmingham B15 2TH, UK.
Birmingham Biomedical Research Centre, National Institute for Health Research (NIHR), University of Birmingham and University Hospitals Birmingham NHS Foundation Trust, Birmingham B15 2TH, UK.
出版信息
Int J Mol Sci. 2021 Jul 14;22(14):7523. doi: 10.3390/ijms22147523.
The increasing disparity between the number of patients listed for transplantation and the number of suitable organs has led to the increasing use of extended criteria donors (ECDs). ECDs are at increased risk of developing ischaemia reperfusion injury and greater risk of post-transplant complications. Ischaemia reperfusion injury is a major complication of organ transplantation defined as the inflammatory changes seen following the disruption and restoration of blood flow to an organ-it is a multifactorial process with the potential to cause both local and systemic organ failure. The utilisation of machine perfusion under normothermic (37 degrees Celsius) and hypothermic (4-10 degrees Celsius) has proven to be a significant advancement in organ preservation and restoration. One of the key benefits is its ability to optimise suboptimal organs for successful transplantation. This review is focused on examining ischaemia reperfusion injury and how machine perfusion ameliorates the graft's response to this.
供移植患者人数与合适器官数量之间的差距不断加大，导致越来越多的人使用扩展标准供体（ECD）。ECD 发生缺血再灌注损伤的风险增加，移植后发生并发症的风险更大。缺血再灌注损伤是器官移植的主要并发症，定义为器官血流中断和恢复后观察到的炎症变化，这是一个多因素过程，有可能导致局部和全身器官衰竭。在正常体温（37 摄氏度）和低温（4-10 摄氏度）下使用机器灌注已被证明是器官保存和恢复的重大进展。其主要优点之一是它能够优化次优器官以实现成功移植。本综述重点研究了缺血再灌注损伤以及机器灌注如何改善移植物对此的反应。
Zotero 插件