Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou, China.
School of Biological Sciences, University of Hong Kong, Hong Kong SAR, China.
Sci Adv. 2023 Feb 15;9(7):eadd5330. doi: 10.1126/sciadv.add5330.
Salt homeostasis is orchestrated by both neural circuits and peripheral endocrine factors. The colon is one of the primary sites for electrolyte absorption, while its potential role in modulating sodium intake remains unclear. Here, we revealed that a gastrointestinal hormone, secretin, is released from colon endocrine cells under body sodium deficiency and is indispensable for inducing salt appetite. As the neural substrate, circulating secretin activates specific receptors in the nucleus of the solitary tracts, which further activates the downstream paraventricular nucleus of the hypothalamus, resulting in enhanced sodium intake. These results demonstrated a previously unrecognized gut-brain pathway for the timely regulation of sodium homeostasis.
盐稳态是由神经回路和外周内分泌因素共同调控的。结肠是电解质吸收的主要部位之一，但其在调节钠摄入方面的潜在作用尚不清楚。在这里，我们揭示了一种胃肠激素——分泌素，它在体内缺钠时从结肠内分泌细胞中释放出来，对于诱导盐食欲是必不可少的。作为神经基质，循环中的分泌素激活孤束核中的特定受体，进一步激活下丘脑室旁核的下游，导致钠摄入量增加。这些结果表明了一条以前未被认识的肠道-大脑通路，用于及时调节钠稳态。
