杂环硼酸催化的脂肪族/芳香族羧酸与胺的脱水酰胺化反应。
Heterocyclic Boron Acid Catalyzed Dehydrative Amidation of Aliphatic/Aromatic Carboxylic Acids with Amines.
机构信息
Shandong Peninsula Engineering Research Center of Comprehensive Brine Utilization, Weifang University of Science and Technology, Shouguang 262700, China.
College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, P. R. China.
出版信息
J Org Chem. 2023 Mar 3;88(5):2832-2840. doi: 10.1021/acs.joc.2c02515. Epub 2023 Feb 15.
A commercially available and versatile dehydrative amidation catalyst, featuring a thianthrene boron acid structure, has been developed. The catalyst shows high catalytic activity to both aliphatic and less reactive aromatic carboxylic acid substrates, including several bioactive or clinical molecules with a carboxylic acid group.
一种商业上可用的、多功能的脱水酰胺化催化剂已经被开发出来，其具有噻蒽硼酸结构。该催化剂对脂肪族和反应性较低的芳香族羧酸底物都表现出很高的催化活性，包括几个具有羧酸基团的生物活性或临床分子。
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