Cavallaro Giuseppe, Lazzara Giuseppe, Milioto Stefana
Dipartimento di Fisica e Chimica, Università degli Studi di Palermo, Viale delle Scienze, pad. 17, 90128 Palermo, Italy; Consorzio Interuniversitario Nazionale per la Scienza e Tecnologia dei Materiali, INSTM, Via G. Giusti, 9, I-50121 Firenze, Italy.
Dipartimento di Fisica e Chimica, Università degli Studi di Palermo, Viale delle Scienze, pad. 17, 90128 Palermo, Italy; Consorzio Interuniversitario Nazionale per la Scienza e Tecnologia dei Materiali, INSTM, Via G. Giusti, 9, I-50121 Firenze, Italy.
Int J Biol Macromol. 2023 Apr 15;234:123645. doi: 10.1016/j.ijbiomac.2023.123645. Epub 2023 Feb 13.
We developed novel composite films based on biocompatible components, such as halloysite clay nanotubes and sulphated galactan (Funori) from red seaweed Gloiopeltis. The filling of the nanotubes within the sulphated galactan matrix was carried out by a green protocol (aqueous casting method) assuring that Funori/halloysite nanocomposites can be totally considered as sustainable materials. The amount of halloysite in the composites was systematically changed to explore the effects of the nanofiller concentration on the mesoscopic properties of the films. We observed that the halloysite content significantly affects the initial water contact angle and the light attenuation coefficient of the Funori based films. These results were interpreted according to SEM images, which showed that the surface morphologies of the nanocomposites depend on the halloysite amounts filled within the polymeric matrix. The mechanical characterization of the nanocomposites was conducted by tensile experiments performed using a linear stress ramp. Moreover, tensile tests were conducted in oscillatory regime at variable temperature to investigate the viscoelastic properties of the nanocomposites. Finally, we filled the biopolymeric matrix with halloysite nanotubes containing sodium diclofenac. The drug release kinetics from the nanocomposites at variable halloysite contents were studied to evaluate their suitability as oral dissolving films for pharmaceutical applications.
我们基于生物相容性成分开发了新型复合薄膜，这些成分包括埃洛石粘土纳米管和来自红藻海萝的硫酸化半乳聚糖（石花菜胶）。通过绿色方法（水相流延法）将纳米管填充到硫酸化半乳聚糖基质中，确保石花菜胶/埃洛石纳米复合材料完全可被视为可持续材料。系统地改变复合材料中埃洛石的含量，以探究纳米填料浓度对薄膜介观性质的影响。我们观察到，埃洛石含量显著影响基于石花菜胶的薄膜的初始水接触角和光衰减系数。根据扫描电子显微镜图像对这些结果进行了解释，图像显示纳米复合材料的表面形态取决于填充在聚合物基质中的埃洛石含量。通过使用线性应力斜坡进行拉伸实验对纳米复合材料进行力学表征。此外，在可变温度下以振荡方式进行拉伸试验，以研究纳米复合材料的粘弹性性质。最后，我们用含有双氯芬酸钠的埃洛石纳米管填充生物聚合物基质。研究了不同埃洛石含量的纳米复合材料的药物释放动力学，以评估它们作为药物应用口服溶膜的适用性。
