Department of Neurology, National Hospital Organization Beppu Medical Center, Japan.
Intern Med. 2023 Oct 15;62(20):3021-3025. doi: 10.2169/internalmedicine.1113-22. Epub 2023 Feb 15.
A 38-year-old woman with untreated Graves' disease was admitted to our hospital because of headache and diplopia for 3 months. A neuro-ophthalmic examination showed bilateral papilledema and abducens nerve paralysis. The cerebrospinal fluid pressure was extremely high. Brain magnetic resonance imaging showed cerebral venous thrombosis in the superior sagittal and right transverse and sigmoid sinuses. Laboratory investigations revealed elevated factor VIII and von Willebrand factor levels. The patient recovered after propylthiouracil and anticoagulation therapy. We herein report a rare case of cerebral venous thrombosis with hyperthyroidism presenting as chronic isolated intracranial hypertension. Hyperthyroidism can induce a hypercoagulable state and lead to venous thromboembolism.
一位 38 岁患有未经治疗的 Graves 病的女性因头痛和复视 3 个月而入院。神经眼科检查显示双侧视盘水肿和外展神经麻痹。脑脊液压力极高。脑部磁共振成像显示上矢状窦和右侧横窦及乙状窦脑静脉血栓形成。实验室检查显示因子 VIII 和血管性血友病因子水平升高。患者接受丙硫氧嘧啶和抗凝治疗后康复。我们在此报告一例罕见的伴有甲状腺功能亢进症的脑静脉血栓形成病例，表现为慢性孤立性颅内高压。甲状腺功能亢进症可引起高凝状态，导致静脉血栓栓塞。
