Department of Respiratory Medicine, Hirosaki University Graduate School of Medicine, Japan.
Department of Respiratory Medicine, Hachinohe City Hospital, Japan.
Intern Med. 2023;62(4):589-593. doi: 10.2169/internalmedicine.1109-22. Epub 2023 Feb 15.
Granulomatosis with polyangiitis (GPA) is a systemic disease that causes vasculitis in various organs. Although the mechanism of pathogenesis remains unclear, infection has been reported to be a causative factor. We herein report a case of GPA that developed following coronavirus disease 2019 (COVID-19) in an adolescent girl. One month after contracting mild COVID-19, the patient had facial allodynia, a fever, and weight loss and was admitted for multiple nodular shadows on a chest roentgenogram. GPA was diagnosed based on pathological findings of the lung and nasal mucosal biopsies. She received methylprednisolone and rituximab, and her symptoms and radiological findings improved.
肉芽肿性多血管炎(GPA)是一种全身性疾病,可导致多种器官的血管炎。尽管发病机制尚不清楚,但已有报道感染是一个致病因素。本文报告了一例青少年 GPA 病例,该患者在感染新型冠状病毒病 2019(COVID-19)后发病。感染轻度 COVID-19 1 个月后,患者出现面部触痛、发热和体重减轻,并因胸部 X 线片上出现多个结节状阴影而住院。根据肺部和鼻黏膜活检的病理结果诊断为 GPA。患者接受了甲基强的松龙和利妥昔单抗治疗,其症状和影像学发现均得到改善。