Department of Nephrology and Rheumatology, Kyorin University School of Medicine, Japan.
Intern Med. 2022 Feb 15;61(4):567-570. doi: 10.2169/internalmedicine.8615-21. Epub 2021 Nov 27.
Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) is a systemic disease that causes vasculitis in various organs. Although the cause of the onset is unknown, infection has been reported to be a causative factor. The subsequent cytokine storm triggered by the immune response against SARS-CoV-2 infection has been reported to lead to symptoms being more severe. We herein report our experience with the onset of AAV following COVID-19 infection. We also report the course of anti-SARS-CoV-2 serum antibody titers following induction therapy, which suggests that vaccination and education concerning standard precautions are necessary in patients who require immunosuppressive therapy, even after COVID-19 infection.
抗中性粒细胞胞质抗体相关性血管炎（AAV）是一种全身性疾病，可导致多种器官的血管炎。虽然发病原因不明，但已有感染被报道为致病因素。对 SARS-CoV-2 感染的免疫反应引发的后续细胞因子风暴已被报道可导致症状更严重。我们在此报告我们在 COVID-19 感染后发生 AAV 的经验。我们还报告了诱导治疗后抗 SARS-CoV-2 血清抗体滴度的变化过程，这表明即使在 COVID-19 感染后，需要免疫抑制治疗的患者仍需要进行疫苗接种和有关标准预防措施的教育。
