Naessig Sara, Pierce Katherine, Ahmad Waleed, Passfall Lara, Krol Oscar, Kummer Nicholas A, Williamson Tyler, Imbo Bailey, Tretiakov Peter, Moattari Kevin, Joujon-Roche Rachel, Zhong Jack, Balouch Eaman, O'Connell Brooke, Maglaras Constance, Diebo Bassel, Lafage Renaud, Lafage Virginie, Vira Shaleen, Hale Steven, Gerling Michael, Protopsaltis Themistocles, Buckland Aaron, Passias Peter G
Department of Orthopaedic Surgery, NYU Langone Orthopedic Hospital, New York, NY, USA.
Department of Orthopedic Surgery, SUNY Downstate, New York, NY, USA.
Int J Spine Surg. 2023 Apr;17(2):168-173. doi: 10.14444/8419. Epub 2023 Feb 15.
Identify the external applicability of the American College of Surgeons' National Surgical Quality Improvement Program (NSQIP) risk calculator in the setting of adult spinal deformity (ASD) and subsets of patients based on deformity and frailty status.
ASD patients were isolated in our single-center database and analyzed for the shared predictive variables displayed in the NSQIP calculator. Patients were stratified by frailty (not frail <0.03, frail 0.3-0.5, severely frail >0.5), deformity [T1 pelvic angle (TPA) > 30, pelvic incidence minus lumbar lordosis (PI-LL) > 20], and reoperation status. Brier scores were calculated for each variable to validate the calculator's predictability in a single center's database (Quality). External validity of the calculator in our ASD patients was assessed via Hosmer-Lemeshow test, which identified whether the differences between observed and expected proportions are significant.
A total of 1606 ASD patients were isolated from the Quality database (48.7 years, 63.8% women, 25.8 kg/m); 33.4% received decompressions, and 100% received a fusion. For each subset of ASD patients, the calculator predicted lower outcome rates than what was identified in the Quality database. The calculator showed poor predictability for frail, deformed, and reoperation patients for the category "any complication" because they had Brier scores closer to 1. External validity of the calculator in each stratified patient group identified that the calculator was not valid, displaying values >0.05.
The NSQIP calculator was not a valid calculator in our single institutional database. It is unable to comment on surgical complications such as return to operating room, surgical site infection, urinary tract infection, and cardiac complications that are typically associated with poor patient outcomes. Physicians should not base their surgical plan solely on the NSQIP calculator but should consider multiple preoperative risk assessment tools.
确定美国外科医师学会国家外科质量改进计划(NSQIP)风险计算器在成人脊柱畸形(ASD)及基于畸形和虚弱状态的患者亚组中的外部适用性。
在我们的单中心数据库中筛选出ASD患者,并分析NSQIP计算器中显示的共享预测变量。患者按虚弱程度(非虚弱<0.03、虚弱0.3 - 0.5、严重虚弱>0.5)、畸形程度[T1骨盆角(TPA)>30、骨盆入射角减去腰椎前凸(PI - LL)>20]和再次手术状态进行分层。计算每个变量的Brier评分,以验证计算器在单中心数据库中的预测能力(质量)。通过Hosmer - Lemeshow检验评估计算器在我们的ASD患者中的外部有效性,该检验确定观察比例与预期比例之间的差异是否显著。
共从质量数据库中筛选出1606例ASD患者(平均年龄48.7岁,63.8%为女性,平均体重指数25.8kg/m²);33.4%的患者接受了减压手术,100%的患者接受了融合手术。对于每个ASD患者亚组,计算器预测的结果发生率低于质量数据库中确定的发生率。对于“任何并发症”类别,计算器对虚弱、畸形和再次手术患者的预测能力较差,因为他们的Brier评分更接近1。在每个分层患者组中,计算器的外部有效性表明该计算器无效,显示的P值>0.05。
NSQIP计算器在我们的单机构数据库中不是一个有效的计算器。它无法对通常与患者不良预后相关的手术并发症(如返回手术室、手术部位感染、尿路感染和心脏并发症)进行评估。医生不应仅基于NSQIP计算器制定手术计划,而应考虑多种术前风险评估工具。