Young John K
Department of Anatomy, Howard University College of Medicine, Washington, DC, United States.
Front Psychol. 2024 Sep 9;15:1467795. doi: 10.3389/fpsyg.2024.1467795. eCollection 2024.
The eating disorders anorexia nervosa and bulimia nervosa are much more common in women than in men. Also, there is evidence for a role of gene mutations in these disorders. This review examines recent data about the possibility that ovarian estrogens may contribute to the symptoms of anorexia nervosa and partly account for the sex difference in incidence of this disorder. Possible mechanisms linking genes that are abnormal in anorexia to pathways that could produce abnormal responses to estrogen are also examined. In addition, recent data pointing to a role of ovarian androgens in the symptoms of bulimia nervosa are reviewed. These data may point to more effective adjustments for the therapy of these difficult to treat disorders.
神经性厌食症和神经性贪食症这两种饮食失调症在女性中比在男性中更为常见。此外，有证据表明基因突变在这些疾病中起作用。本综述探讨了有关卵巢雌激素可能导致神经性厌食症症状并部分解释该疾病发病率性别差异的可能性的最新数据。还研究了将神经性厌食症中异常的基因与可能产生对雌激素异常反应的途径联系起来的可能机制。此外，还综述了近期表明卵巢雄激素在神经性贪食症症状中起作用的数据。这些数据可能为治疗这些难以治疗的疾病指明更有效的调整方向。
