Sota Koichiro, Uchiyama Yuki, Kaida Katsuji, Wakasugi Tatsushi, Takemura Daiki, Sasanuma Naoki, Ikegame Kazuhiro, Domen Kazuhisa
Department of Physical Therapy, School of Rehabilitation, Hyogo Medical University, Kobe, Hyogo, Japan.
Department of Rehabilitation Medicine, Hyogo Medical University, Nishinomiya, Japan.
Prog Rehabil Med. 2023 Feb 8;8:20230003. doi: 10.2490/prm.20230003. eCollection 2023.
This study compared the balance function in patients after allogeneic hematopoietic stem cell transplantation (allo-HSCT) with their balance function after subsequent training sessions with a Balance Exercise Assist Robot (BEAR).
In this prospective observational study, inpatients who underwent allo-HSCT from human leukocyte antigen-mismatched relatives were enrolled from December 2015 to October 2017. Patients were allowed to leave their clean room after allo-HSCT and underwent balance exercise training using the BEAR. Sessions (20-40 min) were performed 5 days per week and consisted of three games that were performed four times each. A total of 15 sessions were performed by each patient. Patient balance function was assessed before BEAR therapy according to the mini-balance evaluation systems test (mini-BESTest), and patients were divided into two groups (Low and High) based on a 70% cut-off value for the total mini-BESTest score. Patient balance was also assessed after BEAR therapy.
Fourteen patients providing written informed consent fulfilled the protocol: six patients in the Low group, and eight patients in the High group. In the Low group, there was a statistically significant difference between pre- and post-evaluations in postural response, which a sub-item of the mini-BESTest. In the High group, there was no significant difference between pre- and post-evaluations in the mini-BESTest.
BEAR sessions improve balance function in patients undergoing allo-HSCT.
本研究比较了异基因造血干细胞移植（allo-HSCT）后患者的平衡功能与随后使用平衡运动辅助机器人（BEAR）进行训练后的平衡功能。
在这项前瞻性观察研究中，2015年12月至2017年10月招募了接受来自人类白细胞抗原不匹配亲属的allo-HSCT的住院患者。allo-HSCT后患者被允许离开洁净室，并使用BEAR进行平衡运动训练。训练课程（20-40分钟）每周进行5天，包括三场游戏，每场游戏进行4次。每位患者共进行15次训练。在BEAR治疗前，根据迷你平衡评估系统测试（mini-BESTest）对患者的平衡功能进行评估，并根据mini-BESTest总分的70%临界值将患者分为两组（低分组和高分组）。BEAR治疗后也对患者的平衡功能进行评估。
14名提供书面知情同意书的患者完成了研究方案：低分组6名患者，高分组8名患者。在低分组中，mini-BESTest的一个子项目姿势反应的评估前后存在统计学显著差异。在高分组中，mini-BESTest评估前后无显著差异。
BEAR训练可改善接受allo-HSCT患者的平衡功能。
