Department of Neurology, The Central Hospital of Shaoyang, Shaoyang, Hunan, China.
Department of Clinical Medicine, Xiangnan University, Chenzhou, Hunan, China.
Front Immunol. 2023 Jan 30;14:1088801. doi: 10.3389/fimmu.2023.1088801. eCollection 2023.
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune-mediated disease characterized by complicated neuropsychiatric symptoms and the detection of cerebrospinal fluid antibodies against the GluN1 subunit of the NMDAR. With the proposed clinical method, more anti-NMDAR encephalitis patients have been discovered since its first report. However, anti-NMDAR encephalitis overlapping with multiple sclerosis (MS) is rare. Herein we report a male patient with anti-NMDAR encephalitis who developed MS in mainland China. Furthermore, we summarized the characteristics of patients who were diagnosed with overlapping MS and anti-NMDAR encephalitis in previous studies. Additionally, we pioneered the use of mycophenolate mofetil in immunosuppressive therapy, providing a novel therapeutic alternative for overlapping anti-NMDAR encephalitis and MS.
抗 N-甲基-D-天冬氨酸受体（NMDAR）脑炎是一种自身免疫性疾病，其特征是神经精神症状复杂，并可检测到针对 NMDAR 的 GluN1 亚单位的脑脊液抗体。随着提出的临床方法，自从首次报道以来，已经发现了更多的抗 NMDAR 脑炎患者。然而，抗 NMDAR 脑炎与多发性硬化症（MS）重叠的情况很少见。在此，我们报告了中国大陆一位患有抗 NMDAR 脑炎的男性患者，随后发展为 MS。此外，我们总结了既往研究中诊断为重叠 MS 和抗 NMDAR 脑炎患者的特征。此外，我们开创性地将霉酚酸酯用于免疫抑制治疗，为重叠的抗 NMDAR 脑炎和 MS 提供了一种新的治疗选择。
