Boutet M, Montminy L, Castonguay A
Department of Pathology, Laval University, Quebec, Canada.
IARC Sci Publ. 1987(84):438-42.
The N-nitrosamine 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK) is abundant in cigarette smoke and is a potent pulmonary carcinogen in Syrian golden hamsters. After intratracheal instillation of NNK to Syrian golden hamsters, we observed focal cell death in the trachea and bronchi followed by cellular regeneration. Regenerating cells were not ciliated and led to mucous-cell hyperplasia followed by squamous-cell metaplasia. Lung alterations consisted of bronchiolar hyperplasia with severe dysplastic changes in association with interstitial pneumonitis. NNK induces preneoplastic cellular changes similar to those observed in the pulmonary epithelium of smokers.
N-亚硝胺4-(N-亚硝基甲基氨基)-1-(3-吡啶基)-1-丁酮(NNK)在香烟烟雾中含量丰富，是叙利亚金黄地鼠的一种强效肺致癌物。将NNK经气管内注入叙利亚金黄地鼠后，我们观察到气管和支气管出现局灶性细胞死亡，随后是细胞再生。再生细胞没有纤毛，导致黏液细胞增生，随后发生鳞状上皮化生。肺部改变包括细支气管增生，并伴有严重的发育异常改变以及间质性肺炎。NNK诱导的肿瘤前细胞变化与吸烟者肺上皮中观察到的变化相似。
