来自滇西石斛的免疫抑制联苄基-苯基丙烷杂合物。
Immunosuppressive Bibenzyl-phenylpropane Hybrids from Dendrobium devonianum.
作者信息
Zhan Rui, Zhang Xin-Yue, Li Zhi-Yuan, Liu Bo, Chen Ye-Gao
机构信息
School of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming, 650050, P. R. China.
Medical Research Center, The Affiliated Hospital of Qingdao University, Qingdao, 266003, China.
出版信息
Chem Biodivers. 2023 Mar;20(3):e202201185. doi: 10.1002/cbdv.202201185. Epub 2023 Mar 2.
Two new bibenzyl-phenylpropane hybrids, dendrophenols A and B (1 and 2), along with nine known bibenzyls, were isolated from the aerial part of Dendrobium devonianum Paxt. Their structures were determined by extensive spectroscopic methods and methylation. Bioassays revealed that compounds 1-9 were specifically immunosuppressive to T lymphocytes with IC values ranging from 0.41 to 9.4 μM, of which compounds 1 (IC =1.62 μM) and 2 (IC =0.41 μM) were promising immunosuppressive agents for T lymphocytes with the selectivity indices of 19.9 and 79.5, respectively.
从滇西石斛（Dendrobium devonianum Paxt.）地上部分分离得到两个新的联苄基-苯丙烷杂合物，即石斛酚A和B（1和2），以及九个已知的联苄类化合物。通过广泛的光谱方法和甲基化反应确定了它们的结构。生物活性测定表明，化合物1-9对T淋巴细胞具有特异性免疫抑制作用，IC值范围为0.41至9.4 μM，其中化合物1（IC = 1.62 μM）和2（IC = 0.41 μM）是有前景的T淋巴细胞免疫抑制剂，选择性指数分别为19.9和79.5。
Zotero 插件