[以全氟三丁胺作为人工氧载体对大鼠小肠进行离体灌注]
[Isolated perfusion of the small intestine of the rat with perfluorotributylamine as an artificial oxygen carrier].
作者信息
Hartmann F, Plauth M, Vieillard-Baron D, Bauder D
机构信息
Med. Univ. Klinik Tübingen, Abt. Innere Medizin I.
出版信息
Infusionsther Klin Ernahr. 1987 Aug;14(4):185-8.
PMID:3679523
Abstract
A new model of isolated intestinal perfusion could be established with fluorocarbon (FC-43) as artificial oxygen carrier. Morphology, cell metabolism of xenobiotics (phase I and II), as well as the transport of a monosaccharide, were stable for at least 2 h. Without interference with the changing metabolism of erythrocytes in the perfusion medium, the proposed model allows one to investigate exclusively the metabolic function of the perfused organ.
摘要
以氟碳化合物（FC-43）作为人工氧载体，可以建立一种新的离体肠灌注模型。形态学、外源性物质的细胞代谢（I期和II期）以及单糖的转运至少在2小时内保持稳定。在不干扰灌注介质中红细胞代谢变化的情况下，该模型能够让人们专门研究被灌注器官的代谢功能。
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