de Oliveira M B, Ishii E L, Yamamoto N S, Bracht A M, Campello A de P, Kluppel M L, Bracht A
Res Commun Chem Pathol Pharmacol. 1986 Aug;53(2):173-81.
The effect of methotrexate, an anti-cancer drug, on carbohydrate metabolism in the isolated perfused rat liver was investigated. Glucose release from endogenous glycogen (glycogenolysis) is strongly activated by methotrexate. The phenomenon shows a well defined concentration dependence: 100% activation occurs at 2.2 X 10(-4) M. Glycolysis and oxygen consumption are only slightly affected.
研究了抗癌药物甲氨蝶呤对离体灌注大鼠肝脏碳水化合物代谢的影响。甲氨蝶呤强烈激活内源性糖原的葡萄糖释放（糖原分解）。该现象呈现出明确的浓度依赖性：在2.2×10⁻⁴ M时出现100%的激活。糖酵解和氧消耗仅受到轻微影响。
