Carlos Simon Foundation-INCLIVA Instituto de Investigación Sanitaria, Valencia, Spain.
Juno Genetics, Rome, Italy.
Physiol Rev. 2023 Jul 1;103(3):1965-2038. doi: 10.1152/physrev.00050.2021. Epub 2023 Feb 16.
Pregnancy is established during the periconceptional period as a continuum beginning with blastocyst attachment to the endometrial epithelial surface followed by embryo invasion and placenta formation. This period sets the foundation for the child and mother's health during pregnancy. Emerging evidence indicates that prevention of downstream pathologies in both the embryo/newborn and pregnant mother may be possible at this stage. In this review, we discuss current advances in the periconceptional space, including the preimplantation human embryo and maternal endometrium. We also discuss the role of the maternal decidua, the periconceptional maternal-embryonic interface, the dialogue between these elements, and the importance of the endometrial microbiome in the implantation process and pregnancy. Finally, we discuss the myometrium in the periconceptional space and review its role in determining pregnancy health.
妊娠是在围孕期建立的，是一个连续的过程，从囊胚附着到子宫内膜上皮表面开始，随后是胚胎侵入和胎盘形成。这一时期为胎儿和母亲在怀孕期间的健康奠定了基础。新出现的证据表明，在这一阶段可能有可能预防胚胎/新生儿和孕妇的下游病理。在这篇综述中，我们讨论了围孕期的最新进展，包括着床前的人类胚胎和母体子宫内膜。我们还讨论了母体蜕膜、围孕期母体-胚胎界面、这些元素之间的对话以及子宫内膜微生物组在着床过程和妊娠中的重要性。最后，我们讨论了围孕期的子宫肌层，并回顾了它在决定妊娠健康中的作用。
