Jung F, Kiesewetter H, Mrowietz C, Leipnitz G, Braun B, Wappler M, Scheffler P, Wenzel E
Department of Clinical Haemostasiology and Transfusion Medicine, University of the Saarland, Homburg/Saar, FRG.
Int J Clin Pharmacol Ther Toxicol. 1987 Sep;25(9):507-14.
In an intraindividual comparison, the effects of a single dose of 600 mg naftidrofuryl on the fluidity of blood, the conjunctival and transcutaneous partial pressure of oxygen and blood flow through the micro- and macrocirculation were compared with placebo, given in random order to a group of 10 women, apparently healthy apart from showing hemorrheological abnormalities. There were significant increases in erythrocyte deformability, conjunctival partial pressure of oxygen, mean blood flow in the common carotid and femoral arteries. All increases were significant compared to both the initial values and the data in the placebo group. The maximal effect was observed after 1.5 h (capillary erythrocyte velocity, blood flow in the common carotid artery) or 3 h (conjunctival partial pressure of oxygen, blood flow in the femoral artery). After 4.5 h all effects had disappeared.
在个体内比较中，将600毫克萘呋胺酯单次给药对血液流动性、结膜和经皮氧分压以及通过微循环和大循环的血流的影响，与安慰剂进行了比较。对一组10名女性以随机顺序给药，这些女性除了有血液流变学异常外，表面上健康。红细胞变形性、结膜氧分压、颈总动脉和股动脉的平均血流均有显著增加。与初始值和安慰剂组的数据相比，所有增加均具有显著性。在1.5小时后观察到最大效应（毛细血管红细胞速度、颈总动脉血流）或3小时后（结膜氧分压、股动脉血流）。4.5小时后所有效应均消失。
